河北中医2026，Vol.48Issue(3)：392-396,400,6.DOI:10.3969/j.issn.1002-2619.2026.03.008
加味黄芪桂枝五物汤联合理筋推拿对椎动脉型颈椎病气虚血瘀证患者转化生长因子β1及血管内皮功能的影响
Effects of modified Huangqi Guizhi Wuwu Decoction combined with tendon Tuina therapy on transforming growth factor-β1 and vascular endothelial function in patients with cervical spondylosis of vertebral artery type with Qi deficiency and blood stasis
摘要
Abstract
Objective To investigate the effect of modified Huangqi Guizhi Wuwu Decoction combined with tendon Tuina therapy for patients with cervical spondylosis of vertebral artery type(Qi deficiency and blood stasis).Methods Totally 138 patients with cervical spondylosis of vertebral artery type(Qi deficiency and blood stasis)who were admitted to the First Department of Bone Injury,Jiangxi Hospital of Integrated Traditional Chinese and Western Medicine from September 2021 to June 2023 were randomized 1∶1 to receive betahistine mesilate tablets(control group)or modified Huangqi Guizhi Wuwu Decoction combined with tendon Tuina therapy(treatment group)for 4 weeks.The aim was to compare the clinical efficacy,neck disability index(NDI),Wechsler Memory Scale-Revised Chinese version(WMS-RC)score,traditional Chinese medicine(TCM)symptom score,serum endothelin-1(ET-1),transforming growth factor-β1(TGF-β1),interleukin-6(IL-6),thromboxane B2(TXB2),and nitric oxide(NO),mean peak flow velocity of the bilateral vertebral and basilar arteries,vertebral horizontal displacement,and vertebral range of motion(ROM)(flexion and extension).Results After treatment,significantly increased WMS-RC,and decreased NDI and TCM symptom scores were detected in the both groups(all P<0.05),and the treatment group was superior to the control group for WMS-RC,INDI and TCM symptom scores(all P<0.05).Significantly decreased ET-1,IL-6,TXB2,TGF-β1,and increased NO were found in the both groups(all P<0.05),which were significantly pronounced in the treatment group(all P<0.05).The peak flow velocity of the bilateral vertebral and basilar arteries in the both groups was significantly increased(P<0.05),which was significantly higher in the treatment group than in the control group(P<0.05).Significantly increased vertebral ROM(flexion and extension),and decreased vertebral horizontal displacement were found in the both groups(all P<0.05),which were significantly pronounced in the treatment group(all P<0.05).The overall effective rate in the treatment group was significantly higher than that in the control group(95.65%[66/69]vs 82.61%[57/69],P<0.05).Conclusion Modified Huangqi Guizhi Wuwu Decoction combined with tendon Tuina therapy can reduce inflammatory response,improve vascular endothelial function,reduce TGF-β1 levels,and promote the recovery of cervical spine function in patients with cervical spondylosis of vertebral artery type(Qi deficiency and blood stasis).关键词
椎动脉型颈椎病/气虚血瘀/黄芪桂枝五物汤/理筋/推拿/血管内皮功能/转化生长因子-β1Key words
Cervical spondylosis of vertebral artery type/Qi deficiency and blood stasis/Huangqi Guizhi Wuwu Decoction/Soothing tendon/Massage/Vascular endothelial function/Transforming growth factor-β1分类
医药卫生引用本文复制引用
陈玲玲,谢水华,孙雷,王星宇..加味黄芪桂枝五物汤联合理筋推拿对椎动脉型颈椎病气虚血瘀证患者转化生长因子β1及血管内皮功能的影响[J].河北中医,2026,48(3):392-396,400,6.基金项目
江西省中医药管理局科技计划项目(编号:2022B839) （编号:2022B839）
