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Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization

Madysen K.Hunter Karen Kessell Dylan Feist Ji Hae Choi Meng-Lun Hsieh Jahnu Saikia Craig L.Duvall Heeseog Kang Andrea I.Alford Kurt D.Hankenson Robert J.Tower Sneha Korlakunta Tristan Maerz Benjamin Levi Neda Vishlaghi Monisha Mittal Kyle Cragg Conan Juan Chase A.Pagani Yuxiao Sun Lindsey Lammlin

骨研究（英文版）2026，Vol.14Issue(1)：141-151,11.

骨研究（英文版）2026，Vol.14Issue(1)：141-151,11.DOI:10.1038/s41413-025-00493-2

Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization

Madysen K.Hunter ¹Karen Kessell ²Dylan Feist ¹Ji Hae Choi ¹Meng-Lun Hsieh ¹Jahnu Saikia ³Craig L.Duvall ³Heeseog Kang ¹Andrea I.Alford ²Kurt D.Hankenson ²Robert J.Tower ¹Sneha Korlakunta ¹Tristan Maerz ²Benjamin Levi ¹Neda Vishlaghi ¹Monisha Mittal ¹Kyle Cragg ²Conan Juan ¹Chase A.Pagani ¹Yuxiao Sun ¹Lindsey Lammlin²

作者信息

1. Center for Organogenesis,Regeneration and Trauma,University of Texas Southwestern,Dallas,TX,USA
2. Department of Orthopedic Surgery,University of Michigan,Ann Arbor,MI,USA
3. Department of Biomedical Engineering,Vanderbilt University,Nashville,TN,USA
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Madysen K.Hunter,Karen Kessell,Dylan Feist,Ji Hae Choi,Meng-Lun Hsieh,Jahnu Saikia,Craig L.Duvall,Heeseog Kang,Andrea I.Alford,Kurt D.Hankenson,Robert J.Tower,Sneha Korlakunta,Tristan Maerz,Benjamin Levi,Neda Vishlaghi,Monisha Mittal,Kyle Cragg,Conan Juan,Chase A.Pagani,Yuxiao Sun,Lindsey Lammlin..Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization[J].骨研究（英文版）,2026,14(1):141-151,11.

基金项目

We would like to thank S.Harris,A.Boppana,and X.Sun from the Department of Radiology at the University of Texas Southwestern for assisting in uCT imaging.We would also like to thank the University of Texas Southwestern Metabolomics Facility for single-cell sequencing and spatial transcriptomics assistance.Some of the visualizations in this manuscript were generated on BioRender.com.We would like to express gratitude for support from the Department of Defense grant HT9425-23-1-0327 and the National Institutes of Health R01AR078324.The University of Texas Southwestern Medical Center—Dallas holds a Physician—Scientist Institutional Award from the Burroughs Wellcome Fund(M.K.H.)... （M.K.H.）

骨研究（英文版）

ISSN：2095-4700

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