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PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice

Weixin Zhang Arryn D.Otte Zhuolun Wang Sisir Kumar Barik Mei Wan Xu Cao Janet L.Crane

骨研究（英文版）2026，Vol.14Issue(1)：152-165,14.

骨研究（英文版）2026，Vol.14Issue(1)：152-165,14.DOI:10.1038/s41413-025-00488-z

PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice

Weixin Zhang ¹Arryn D.Otte ²Zhuolun Wang ³Sisir Kumar Barik ²Mei Wan ⁴Xu Cao ⁴Janet L.Crane¹

作者信息

1. Department of Orthopedic Surgery,Johns Hopkins University School of Medicine,Baltimore,MD,USA||Division of Pediatric Endocrinology,Johns Hopkins University School of Medicine,Baltimore,MD,USA
2. Division of Pediatric Endocrinology,Johns Hopkins University School of Medicine,Baltimore,MD,USA
3. Department of Neurology,Johns Hopkins University School of Medicine,Baltimore,MD,USA
4. Department of Orthopedic Surgery,Johns Hopkins University School of Medicine,Baltimore,MD,USA
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摘要

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Weixin Zhang,Arryn D.Otte,Zhuolun Wang,Sisir Kumar Barik,Mei Wan,Xu Cao,Janet L.Crane..PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice[J].骨研究（英文版）,2026,14(1):152-165,14.

基金项目

This research was supported by the U.S.Department of Health&Human Services NIH National Institute on Aging under Award Number P01AG066603(to J.C.). （to J.C.）

骨研究（英文版）

ISSN：2095-4700

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