骨研究（英文版）2026，Vol.14Issue(1)：291-302,12.DOI:10.1038/s41413-025-00500-6
Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network
Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network
Raquel Ruiz-Hernández 1Maria M.Caffarel 2Daniela Gerovska 3Marcos J.Araúzo-Bravo 4Amaia Vilas 5Felipe Prosper 6Sergio Moya 7Daniel Alonso-Alconada 8Ana Alonso-Varona 8Gretel Nusspaumer 9Javier Lopez-Rios 9Laurie Gay 10Karine Rizotti 11Robin Lovell-Badge 11Dominique Bonnet 12Ilaria Malanchi 10Ander Abarrategi 1Verónica Moncho-Amor 13Pablo Martín 1Jhonatan A.Vergara-Arce 7Stefania Di Blasio 14Thomas Snoeks 15Unai Cossío 7Ander Matheu16
作者信息
- 1. Department of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,Spain||Center for Cooperative Research in Biomaterials(CIC biomaGUNE),Basque Research and Technology Alliance(BRTA),Donostia-San Sebastian,Spain
- 2. Biogipuzkoa Health Research Institute,San Sebastián,Spain||IKERBASQUE,Basque Foundation for Science,Bilbao,Spain
- 3. Biogipuzkoa Health Research Institute,San Sebastián,Spain
- 4. Department of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,Spain||Biogipuzkoa Health Research Institute,San Sebastián,Spain||IKERBASQUE,Basque Foundation for Science,Bilbao,Spain
- 5. Department of Hematology-Oncology,Instituto de Investigación Sanitaria de Navarra(IDISNA),CIMA Universidad de Navarra,Pamplona,Spain
- 6. Department of Hematology-Oncology,Instituto de Investigación Sanitaria de Navarra(IDISNA),CIMA Universidad de Navarra,Pamplona,Spain||Centro de Investigación Biomédica en Red de Cáncer,CIBERONC,Instituto de Salud Carlos III,Madrid,Spain
- 7. Center for Cooperative Research in Biomaterials(CIC biomaGUNE),Basque Research and Technology Alliance(BRTA),Donostia-San Sebastian,Spain
- 8. Department of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,Spain
- 9. Centro Andaluz de Biología del Desarrollo(CABD),CSIC-Universidad Pablo de Olavide-Junta de Andalucía,Seville,Spain
- 10. Tumour-Host Interaction Laboratory,The Francis Crick Institute,London,UK
- 11. Stem Cell Biology and Developmental Genetics Laboratory,The Francis Crick Institute,London,UK
- 12. Haematopoietic Stem Cell Laboratory,The Francis Crick Institute,London,UK
- 13. Stem Cell Biology and Developmental Genetics Laboratory,The Francis Crick Institute,London,UK||Biogipuzkoa Health Research Institute,San Sebastián,Spain
- 14. Tumour-Host Interaction Laboratory,The Francis Crick Institute,London,UK||Laboratory of Cancer Pathology,Center for Advanced Studies and Technology(CAST),University"G.D'Annunzio",Chieti,Italy
- 15. Biological Research Facility,The Francis Crick Institute,London,UK
- 16. Biogipuzkoa Health Research Institute,San Sebastián,Spain||IKERBASQUE,Basque Foundation for Science,Bilbao,Spain||Centro de Investigación Biomédica de fragilidad y envejecimiento,CIBERFES,Instituto de Salud Carlos III,Madrid,Spain
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Raquel Ruiz-Hernández,Maria M.Caffarel,Daniela Gerovska,Marcos J.Araúzo-Bravo,Amaia Vilas,Felipe Prosper,Sergio Moya,Daniel Alonso-Alconada,Ana Alonso-Varona,Gretel Nusspaumer,Javier Lopez-Rios,Laurie Gay,Karine Rizotti,Robin Lovell-Badge,Dominique Bonnet,Ilaria Malanchi,Ander Abarrategi,Verónica Moncho-Amor,Pablo Martín,Jhonatan A.Vergara-Arce,Stefania Di Blasio,Thomas Snoeks,Unai Cossío,Ander Matheu..Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network[J].骨研究（英文版）,2026,14(1):291-302,12.基金项目
The authors would like to thank the staff at CIC biomaGUNE core facility platforms.This work was funded by Grants PID2021-127191OB-I00,RTI2018-101708-A-I00,PRE2018-084542 and PRE2022-102680 funded by MCIN/AEI/10.13039/501100011033 and by"ERDF A way of making Europe".Grant RYC2018-025502-I is funded by MCIN/AEI/10.13039/501100011033 and by"ESF Investing in your future".Grant MDM-2017-0720 Maria de Maeztu Units of Excellence Program funded by the Spanish State Research Agency.D.G.and M.J.A.-B.were supported by Instituto de Salud Carlos III,Infrastructure of Precision Medicine associated with Science and Technology(IMPaCT)of the Strategic Action in Health(iDATA-MP). （IMPaCT）
