化学试剂2026，Vol.48Issue(3)：12-18,7.DOI:10.13822/j.cnki.hxsj.2025.0318
碱促进下2,3-二取代苯并呋喃的高效合成
Base-Promoted Efficient Synthesis of 2,3-Disubstituted Benzofurans
摘要
Abstract
Benzofuran is a heterocyclic structural unit that occurs widely in natural products,drugs,pesticides,and functional materials,and it is used as a potential synthetic building block in preparing various biologically active molecules.The synthesis of benzofuran cores is well-established,but efficient general methods of synthesizing 2,3-disubstituted benzofurans remain relatively limited.Several reported methods often suffer from challenges,such as harsh reaction conditions,cumbersome steps,and poor substrate generalities,and thus,developing a facile,mild,efficient,operationally simple synthetic method is necessary.This study designed a method of synthesizing 2,3-disubstituted benzofuran derivatives using easily prepared o-hydroxychalcones and commercially available γ-bromocrotonates as starting materials.The reaction proceeded via a one-pot multistep tandem process under mildly basic conditions.This strategy avoided the use of expensive metal catalysts and harsh reaction conditions,demonstrating a good functional-group compatibility and operational simplicity.This synthetic strategy provided a novel approach for use in efficiently synthesizing 2,3-disubstituted benzofuran derivatives.It also laid a solid foundation for further in-depth research into their biological activities and material properties,displaying potential for application in the fields of medicinal chemistry and organic synthesis.关键词
苯并呋喃/合成/碱促进/邻羟基查尔酮/γ-溴代巴豆酸酯Key words
benzofuran/synthesis/base promotion/o-hydroxychalcone/γ-bromocrotonate分类
化学化工引用本文复制引用
张金坤,李芷乐,邱小权,黄年玉,王能中..碱促进下2,3-二取代苯并呋喃的高效合成[J].化学试剂,2026,48(3):12-18,7.基金项目
湖北省中央引导地方科技发展资金项目(2024BSB016) （2024BSB016）
湖北省自然科学基金宜昌创新发展联合基金重点项目(2025AFD262). （2025AFD262）
