化学试剂2026，Vol.48Issue(3)：27-41,15.DOI:10.13822/j.cnki.hxsj.2026.0001
共价有机笼在药物递送、生物成像和生物传感中的研究进展
Research Progress of Covalent Organic Cages in Drug Delivery,Bioimaging,and Biosensing
摘要
Abstract
Covalent organic cages(COCs)are a class of discrete cage-like functional materials constructed from small organic molecules via covalent bonding and feature tunable cavity sizes,well-defined structures,high chemical stability,and excellent solution processability.In recent years,COCs have demonstrated enormous application potential in the biomedical field,achieving remarkable progress in three key areas in particular:Drug delivery,bioimaging,and biosensing.For drug delivery,COCs that achieve the highly selective encapsulation of various drugs,such as aromatic and hydrophobic agents,have been developed through precise structural design and functional modification.Combined with stimulus-responsive mechanisms,including pH,redox,and enzyme responsiveness,these COCs enable targeted and controlled drug release,significantly enhancing therapeutic efficacy while reducing side effects.For bioimaging,COCs can be engineered into single-modal and multimodal imaging probes(e.g.,fluorescence,magnetic resonance,and PET)that exhibit high sensitivity,low bioaccumulation risk,and favorable biocompatibility by incorporating fluorescent modules,chelating paramagnetic metal ions,or loading radionuclides.Further,owing to their precisely defined molecular cavities and controllable surface chemistry,COCs can realize the highly specific recognition and signal transduction of ATP,reactive oxygen species,metal ions,and biomarkers,thereby exhibiting outstanding performance in biosensing.This review systematically summarized the structural design,synthetic strategies,and biological functionalization methods of COCs,focusing on their mechanisms of action and representative applications in the above three areas.It also analyzed the key challenges faced by COCs in terms of their biological stability,in vivo metabolism,and large-scale production.Finally,the future development directions of COCs in precision medicine,early disease screening,and other fields were discussed,providing references for related research.关键词
共价有机笼/动态共价化学/药物递送/生物成像/生物传感Key words
covalent organic cages/dynamic covalent chemistry/drug delivery/bioimaging/biosensing分类
化学化工引用本文复制引用
王满江,于江,魏会强,侯文彬,李祎亮..共价有机笼在药物递送、生物成像和生物传感中的研究进展[J].化学试剂,2026,48(3):27-41,15.基金项目
国家自然科学基金项目(82404449). （82404449）
