化学试剂2026，Vol.48Issue(3)：87-94,8.DOI:10.13822/j.cnki.hxsj.2025.0271
复杂基质中新精神活性物质分析方法研究进展
Research Progress into Analytical Methods for New Psychoactive Substances in Complex Matrices
摘要
Abstract
New psychoactive substances(NPS)are chemical entities that have not yet been scheduled under international drug control conventions,possess abuse potential,and pose serious threats to public health.These substances often exploit structural modifications to circumvent legal controls,thereby presenting significant regulatory challenges and public-health-protection obstacles.Establishing efficient and reliable analytical detection methods for monitoring and controlling NPS is therefore an important objective.This article reviewed recent advances in sample-pretreatment techniques and analytical-detection methods for NPS in complex matrices.Sample-pretreatment methods such as solid-phase extraction,liquid-phase microextraction,and QuEChERS have been widely used to extract and purify NPS from complex samples,including biological fluids,wastewater,and hair.However,some issues,including cumbersome procedures and inconsistent recovery rates,remain.Analytical-detection techniques such as gas chromatography-mass spectrometry and liquid chromatography-high-resolution mass spectrometry have become primary tools for identifying MPS structures and analyzing them quantitatively.Among these,high-resolution mass spectrometry plays a key role in identifying unknown NPS owing to its high sensitivity and accurate mass-measuring capability.Nevertheless,existing methods still face limitations,including long analytical cycles,high dependences on specialized equipment,and delayed responses to newly emerging structural analogs.Future developments are anticipated to focus on simpler,more-efficient,and automated pretreatment techniques,along with rapid,high-throughput,and on-site analytical approaches aimed at making NPS identification more efficient and reducing regulatory gaps for chemically modified analogs.关键词
新精神活性物质/样品前处理/分析检测方法/液相色谱-高分辨质谱/高通量分析/药物滥用监测Key words
new psychoactive substances(NPS)/sample pretreatment/analytical detection methods/liquid chromatography-high-resolution mass spectrometry(LC-HRMS)/high-throughput analysis/drug abuse monitoring分类
化学化工引用本文复制引用
邹秀静,贺锦灿,李亚庆,姚宏忠,程良红,张毅..复杂基质中新精神活性物质分析方法研究进展[J].化学试剂,2026,48(3):87-94,8.基金项目
广东省证据材料司法鉴定(南天)工程技术研究中心开放课题基金资助项目(ETRC202307). （南天）
