中国当代医药2026，Vol.33Issue(4)：44-49,6.DOI:10.3969/j.issn.1674-4721.2026.04.08
射麻口服液联合噻托溴铵在慢性阻塞性肺疾病急性加重期痰热壅肺证患者中的应用效果
Application effect of Shema Oral Liquid combined with Tiotropium Bro-mide in patients with phlegm-heat obstructing lung syndrome in the acute exacerbation stage of chronic obstructive pulmonary disease
摘要
Abstract
Objective To explore the therapeutic effect of Shema Oral Liquid combined with Tiotropium Bromide in the treatment of phlegm-heat obstructing lung syndrome in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its influence on cardiopulmonary function and inflammation.Methods A total of 80 patients diag-nosed with phlegm-heat obstructing lung syndrome of AECOPD in Jiujiang First Peo ple's Hospital Development Zone Branch from October 2022 to April 2024 were selected and divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with Tiotropium Bromide on the basis of standardized treatment,and the observation group was treated with Shema Oral Liquid on the basis of control group.The differences of clinical efficacy,traditional Chinese medicine syndrome quantitative score,heart function index,lung function index,inflammatory response index and incidence of adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group;the quantitative score of traditional Chinese medicine syndrome,heart function index,lung function in-dex and inflammatory response index of 2 groups showed significant time effect,intergroup effect and interaction ef-fect between time and group;the traditional Chinese medicine syndrome quantification scores,left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),right ventricular end-systolic diameter(RVESD),high mobility group protein B1(HMGB1),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group;left ventricular ejection fraction(LVEF),right ventricular ejection fraction(RVEF),peak flow velocity(PEF),forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and FEV1/FVC in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).There was no sta-tistically significant difference in the overall incidence of adverse reactions between the two groups(P＞0.05).Conclusion Shema Oral Liquid combined with Tiotropium Bromide in the treatment of AECOPD syndrome of phlegm heat obstruction can effectively improve the total effective rate of clinical treatment,promote the recovery of cardiopulmonary function,reduce inflammation,and have the same safety as tiotropium bromide alone.关键词
射麻口服液/噻托溴铵/慢性阻塞性肺疾病急性加重期/痰热壅肺证/临床疗效Key words
Shema Oral Liquid/Tiotropium Bromide/Acute exacerbation of chronic obstructive pulmonary disease/Syn-drome of phlegm-heat obstructing lung/Clinical effect分类
医药卫生引用本文复制引用
章秀,汪聪聪,熊琪,王浩霞,胡跞天,徐兰芳..射麻口服液联合噻托溴铵在慢性阻塞性肺疾病急性加重期痰热壅肺证患者中的应用效果[J].中国当代医药,2026,33(4):44-49,6.基金项目
江西省卫生健康委科技计划项目(202211891). （202211891）
