解剖学杂志2026，Vol.49Issue(1)：19-23,5.DOI:10.3969/j.issn.1001-1633.2026.01.004
原发性衰老相关性tau蛋白病和阿尔茨海默病早期阶段的样本分析
Sample analysis of primary age-related tauopathy and early-stage Alzheimer's disease
陆辉 1李耀 2毛峥嵘 2竺可青 3孙冰 3吴娟利 3章京 3周韧2
作者信息
- 1. 浙江大学 医学院和浙江大学司法鉴定中心,杭州 310058||复旦大学基础医学院人体解剖学与组织学胚胎学系,上海 200032
- 2. 浙江大学 医学院和浙江大学司法鉴定中心,杭州 310058
- 3. 浙江大学 医学院国家健康和疾病人脑组织资源库,杭州 310058
- 折叠
摘要
Abstract
Objective:To investigate the pathologic changes of primary age-related tauopathy(PART)and early stage of Alzheimer's disease(pre-AD)in Chinese human brain samples,with the aim to provide a basis for the clinical diagnosis and pathological classification.Methods:Demographic,anatomical,neuropathological,and clinical data of PART and pre-AD samples were collected,and pathological diagnosis was performed through various morphological staining methods including hematoxylin-eosin(H-E)staining,special staining and immunohistochemistry,followed by statistical analysis of relevant data.Results:There were statistically significant differences between the PART and pre-AD groups in the pathological changes of cerebral amyloid angiopathy(CAA).CAA was present in only one case in the PART group,while the proportion of the pre-AD group reached 25.9%.The expression rates of TDP43 and p62 in the pre-AD group were higher than those of the PART group.No statistically significant differences were found between the groups in brain weight,cerebrospinal fluid pH,or Braak stage.Conclusion:Differences in certain pathologic indicators between PART and pre-AD in Chinese brain samples may be related to age at death.关键词
原发性衰老相关性tau病/阿尔茨海默病/神经原纤维缠结/脑库Key words
primary age-related tauopathy/Alzheimer's disease/neurofibrillary tangles/brain bank分类
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陆辉,李耀,毛峥嵘,竺可青,孙冰,吴娟利,章京,周韧..原发性衰老相关性tau蛋白病和阿尔茨海默病早期阶段的样本分析[J].解剖学杂志,2026,49(1):19-23,5.
