检验医学与临床2026，Vol.23Issue(6)：809-814,821,7.DOI:10.3969/j.issn.1672-9455.2026.06.015
血清GGT、Gal-3对慢性心力衰竭并发心律失常患者预后不良的预测价值
Predictive value of serum γ-glutamyltransferase and galectin-3 for poor prognosis in patients with chronic heart failure complicated by arrhythmia
摘要
Abstract
Objective To investigate the predictive value of serum γ-glutamyltransferase(GGT)and galec-tin-3(Gal-3)for poor prognosis in patients with chronic heart failure(CHF)complicated by arrhythmia.Methods A total of 121 patients with CHF complicated by arrhythmia admitted to Chuzhou First People's Hospital from June 2022 to January 2024 were selected as the study group.Based on their prognosis,these pa-tients were further divided into a poor-prognosis subgroup and a good-prognosis subgroup.Additionally,121 patients with CHF alone and 121 healthy individuals undergoing physical examinations during the same period were selected as the CHF group and the control group respectively.Serum levels of GGT and Gal-3 among the groups,along with cardiac function parameters[brain natriuretic peptide(BNP)and left ventricular ejection fraction(LVEF)],were compared between the poor-prognosis group and good-prognosis group.Multivariate Logistic regression analysis was used to identify influencing factors for poor prognosis in patients with CHF complicated by arrhythmia.Receiver operating characteristic(ROC)curve was utilized to analyze the predic-tive value of serum GGT and Gal-3 for poor prognosis.Results Serum levels of GGT and Gal-3 in the study group were significantly higher than those in the CHF and control groups,and levels in the CHF group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Compared with the good-prognosis subgroup,levels of GGT,Gal-3 and BNP were significantly elevated(P<0.05),whereas LVEF was significantly reduced in the poor-prognosis subgroup(P<0.05).BNP,LVEF,GGT,and Gal-3 were identified as influencing factors for poor prognosis in patients with CHF compli-cated by arrhythmia(P<0.05).The areas under the curve(AUCs)for serum GGT and Gal-3 in predicting poor prognosis were 0.836 and 0.848 respectively.The AUC for the combined prediction was 0.925,which was significantly greater than that of each individual indicator(Zcombination vs.GGT=2.071,P=0.038;Zcombination vs.Gal-3=2.185,P=0.029).Conclusion Elevated serum levels of GGT and Gal-3 in patients with CHF complicated by arrhythmia are both risk factors for poor prognosis.The combination of these two biomarkers demonstrates high predictive value for poor prognosis in such patients.关键词
慢性心力衰竭/心律失常/γ-谷氨酰转移酶/半乳糖凝集素-3/预后Key words
chronic heart failure/arrhythmia/γ-glutamyltransferase/galectin-3/prognosis分类
医药卫生引用本文复制引用
刘玉,吴频霞,徐小红,刘亚圆,杨诺言..血清GGT、Gal-3对慢性心力衰竭并发心律失常患者预后不良的预测价值[J].检验医学与临床,2026,23(6):809-814,821,7.基金项目
安徽省滁州市科技计划项目(2023ZD034). （2023ZD034）
