检验医学与临床2026，Vol.23Issue(6)：815-821,7.DOI:10.3969/j.issn.1672-9455.2026.06.016
项五针联合重复经颅磁刺激治疗脑卒中后吞咽功能障碍的疗效及对BDNF、VILIP-1水平的影响
Efficacy of five-needle-in-nape acupuncture combined with repetitive transcranial magnetic stimulation for post-stroke dysphagia and its effects on BDNF and VILIP-1 levels
摘要
Abstract
Objective To investigate the efficacy of five-needle-in-nape acupuncture combined with repeti-tive transcranial magnetic stimulation(rTMS)in treating dysphagia after stroke(DAS)and its effects on ser-um levels of brain-derived neurotrophic factor(BDNF)and visinin-like protein 1(VILIP-1).Methods A total of 120 patients with DAS admitted to the hospital from December 2022 to December 2024 were selected as study subjects.According to a random number table,the patients were allocated to an rTMS group and a com-bination group,with 60 patients in each group.The rTMS group received conventional treatment plus rTMS,while the combination group received five-needle-in-nape acupuncture in addition to the rTMS group's regi-men.Clinical efficacy,swallowing function,DAS severity,neurotrophic factor(BDNF and VILIP-1)levels,feeding ability and quality of life were assessed in both groups.Results After the intervention,the total clini-cal effective rate in the combination group was 95.00%,which was significantly higher than 80.00%in the rTMS group(P<0.05).After the intervention,the Standardized Swallowing Assessment(SSA)scores and serum VILIP-1 level were significantly decreased compared with those before the intervention in both groups(P<0.05),and were lower in the combination group than those in the rTMS group(P<0.05).After treat-ment,the Dysphagia Outcome and Severity Scale(DOSS)scores,Functional Oral Intake Scale(FOIS)scores,Activity of Daily Living(ADL)scale scores,Swallowing-Related Quality of Life(SWAL-QOL)questionnaire scores and serum BDNF level were significantly increased compared with those before the intervention in both groups(P<0.05),and all were significantly higher in the combination group than those in the rTMS group(P<0.05).Conclusion The application of five-needle-in-nape acupuncture combined with rTMS for DAS can enhance clinical efficacy,reduce the severity of dysphagia,improve swallowing function and oral intake ability,elevate serum BDNF level,lower VILIP-1 level,and improve activities of daily living.关键词
项五针/脑卒中/吞咽功能障碍/重复经颅磁刺激/视锥蛋白样蛋白1/脑源性神经营养因子Key words
five-needle-in-nape acupuncture/stroke/dysphagia/repetitive transcranial magnetic stimulation/visinin-like protein 1/brain-derived neurotrophic factor分类
医药卫生引用本文复制引用
李永芹,张静玺,王洁,贾永芳,谢玉洁..项五针联合重复经颅磁刺激治疗脑卒中后吞咽功能障碍的疗效及对BDNF、VILIP-1水平的影响[J].检验医学与临床,2026,23(6):815-821,7.基金项目
河北省中医药管理局项目(2024522). （2024522）
