摘要
Abstract
Objective To investigate the predictive value of serum fibroblast growth factor 23(FGF-23),C1q/tumor necrosis factor-related protein 3(CTRP3)and microRNA-30b(miR-30b)for vascular calcification(VC)in maintenance hemodialysis(MHD)patients.Methods A total of 220 MHD patients treated at the hospital from January 2022 to December 2024 were selected as study subjects.VC status was assessed using X-ray radiography,and patients were categorized into three groups based on the Kauppila calcification score:a non-calcification group(0 points),a mild calcification group(1-4 points)and a moderate-to-severe calcifica-tion group(>4 points).Baseline characteristics,as well as serum levels of FGF-23,CTRP3 and miR-30b,were compared among the three groups.The correlation between these serum biomarkers and the degree of VC was analyzed.The predictive value of serum FGF-23,CTRP3 and miR-30b for VC in MHD patients was evaluated using receiver operating characteristic(ROC)curve analysis.Results Dialysis duration was significantly lon-ger in the moderate-to-severe calcification group compared with the mild and non-calcification groups(P<0.05),and it was also significantly longer in the mild calcification group than that in the non-calcification group(P<0.05).Serum levels of calcium(Ca),phosphorus(P),parathyroid hormone(PTH),FGF-23 and CTRP3 were significantly higher in the moderate-to-severe group than those in the other two groups(P<0.05),while miR-30b level was lower(P<0.05).Similarly,the levels of Ca,P,PTH,FGF-23 and CTRP3 in the mild calcification group were significantly higher than those in the non-calcification group(P<0.05),whereas the miR-30b level was lower(P<0.05).Dialysis duration and serum levels of Ca,P,PTH,FGF-23 and CTRP3 were positively correlated with the degree of VC(P<0.05),whereas miR-30b level was negative-ly correlated(P<0.05).ROC curve analysis showed that the areas under the curve of FGF-23,CTRP3 and miR-30b for predicting VC were 0.894,0.901 and 0.844 respectively(P<0.05).Conclusion In MHD pa-tients with VC,serum levels of FGF-23 and CTRP3 are elevated,while miR-30b level is decreased.FGF-23,CTRP3 and miR-30b are all associated with the development of VC in MHD patients and can serve as predic-tive biomarkers in clinical practice.关键词
维持性血液透析/成纤维细胞生长因子23/C1q/肿瘤坏死因子相关蛋白3/微小RNA-30b/血管钙化/预测价值Key words
maintenance hemodialysis/fibroblast growth factor 23/C1q/tumor necrosis factor-related protein 3/microRNA-30b/vascular calcification/predictive value分类
医药卫生
