检验医学与临床2026，Vol.23Issue(6)：858-864,7.DOI:10.3969/j.issn.1672-9455.2026.06.022
早发冠心病影响因素的研究进展
Advances in research on influencing factors for premature coronary heart disease
摘要
Abstract
Coronary heart disease(CHD)is traditionally considered a disease of the elderly;however,a sig-nificant trend toward a younger age of onset has been observed in recent years.Premature coronary heart dis-ease(PCHD)is defined as CHD occurring in men aged<55 years and women aged<65 years.Given that the etiology in some patients with PCHD cannot be fully explained by traditional risk factors,an in-depth ex-ploration of its multi-factorial interaction mechanisms and novel biomarkers is urgently required.This article systematically reviews the multi-dimensional risk factors for PCHD,including genetic,inflammatory,metabol-ic,environmental and behavioral aspects,as well as their interactions.It also summarizes research progress in emerging fields,such as gut microbiota and non-coding RNA,along with novel biomarkers.Furthermore,this review outlines advances in PCHD-related risk prediction models,analyzes the limitations of existing models,and discusses future directions for improvement,specifically regarding the integration of multi-dimensional da-ta and the utilization of machine learning algorithms to construct precise prediction models.Finally,based on a comprehensive analysis of the aforementioned multi-factorial interactions,this review highlights the limita-tions of current research and provides an outlook on future research directions,aiming to offer novel insights for the early prevention and treatment of PCHD and to improve cardiovascular health outcomes in younger populations.关键词
早发冠心病/影响因素/交互作用/遗传/炎症/代谢/环境暴露/风险预测模型Key words
premature coronary heart disease/influencing factor/interaction/genetics/inflamma-tion/metabolism/environmental exposure/risk prediction model分类
医药卫生引用本文复制引用
郭晋田,李凌..早发冠心病影响因素的研究进展[J].检验医学与临床,2026,23(6):858-864,7.基金项目
山西省科技厅项目(2022D100062062016334405485775). （2022D100062062016334405485775）
