高师理科学刊2026，Vol.46Issue(2)：51-56,6.DOI:10.3969/j.issn.1007-9831.2026.02.009
金合欢素对酒精诱导小鼠肝损伤的保护作用
Protective effect of acacetin against alcohol-induced liver injury in mice
摘要
Abstract
Aims to investigate the effects of acacia saponin on alcohol-induced liver tissue damage in mice.After inducing liver injury through alcohol gavage,mice were euthanized,body mass and liver mass were measured,liver morphological changes were observed via HE staining,alanine aminotransferase activity in serum was detected using a kit,and mRNA expression levels of inflammatory factor-related genes IL-6,IL-10,TNFα and antioxidant-related genes SOD,Nrf2,HO-1,NQO1 were assessed.Results showed that compared with the control group(CK)mice in the model group(Model)exhibited significantly elevated serum ALT activity,upregulation of mRNA expression levels for pro-inflammatory genes,and downregulation of mRNA expression levels for antioxidant-related genes.Compared with the Model group,both the low-dose acacia-lactone intervention group(Model+LACA)and the high-dose intervention group(Model+HACA)exhibited significantly reduced ALT activity,decreased mRNA expression levels of pro-inflammatory genes,and increased mRNA expression levels of antioxidant enzyme genes.The results indicate that acacia reticulata extract alleviates alcohol-induced liver injury in mice.These findings provide experimental evidence supporting the application of acacia reticulata extract in the prevention and treatment of alcoholic liver disease.关键词
酒精性肝损伤/氧化应激/金合欢素Key words
alcohol-related liver injury/oxidative stress/acacetin分类
生物科学引用本文复制引用
刘家宝,王玉卉,张伟伟..金合欢素对酒精诱导小鼠肝损伤的保护作用[J].高师理科学刊,2026,46(2):51-56,6.基金项目
黑龙江省省属高等学校基本科研业务费科研项目(145209515) （145209515）
齐齐哈尔大学研究生创新科研项目(QUZLTS_CX2024023) （QUZLTS_CX2024023）
