岭南现代临床外科2026，Vol.26Issue(1)：33-41,9.DOI:10.3969/j.issn.1009-976X.2026.01.005
成纤维细胞乙醇脱氢酶1B基因在腹主动脉瘤中的潜在作用
Identification and validation of a carbohydrate metabolism related key gene associated with fibro-blast in abdominal aortic aneurysm
摘要
Abstract
Objective To explore the potential role of the(alcohol dehydrogenase 1B,ADH1B)ADH1B gene in abdominal aortic aneurysms(AAA).Methods Utilizing bioinformatics techniques,we conducted a comprehensive analysis of transcriptome and single-cell data from human AAA and normal abdominal aorta tissue samples.The metabolism-related marker gene ADH1B was identified using logistic regression analysis of carbohydrate metabolism datasets.Results The fibroblast ADH1B gene may be involved in protecting against the development of AAA by modulating smooth muscle cell phenotypic changes.Conclusion The ADH1B gene appears to have a protective role in abdominal aortic aneurysms.关键词
ADH1B/腹主动脉瘤/生物信息学Key words
ADH1B/abdominal aortic aneurysms/bioinformatics分类
医药卫生引用本文复制引用
李根,赵子牛,石展岳..成纤维细胞乙醇脱氢酶1B基因在腹主动脉瘤中的潜在作用[J].岭南现代临床外科,2026,26(1):33-41,9.基金项目
国家自然科学基金(82271806) （82271806）
阜外华中心血管病医院科研培育项目(FWKY250038 （）
FWKY240009) （）
