岭南现代临床外科2026，Vol.26Issue(1)：62-67,6.DOI:10.3969/j.issn.1009-976X.2026.01.009
常见环境内分泌干扰物对尿道下裂的影响
Effects of common endocrine disrupting chemicals on hypospadias
摘要
Abstract
Hypospadias is a relatively common congenital malformation of the pediatric genitourinary system,and its incidence has been increasing worldwide in recent years.This disorder not only leads to abnormal micturition and penile developmental malformations,but may also have an adverse psychologi-cal effect on affected children due to penile morphological anomalies and the resulting social stress.In etiological research on hypospadias,epidemiological studies have shown that exposure to endocrine-disrupting chemicals(EDCs)is an important environmental factor that increases the risk of this disease.This paper systematically reviews the main categories of EDCs and their primary exposure routes,and focuses on exploring their pathogenic mechanisms from four aspects:interfering with hormonal signals,impairing the developmental microenvironment and molecular dynamics,affecting and affecting the pro-gesterone receptorhypothesis and the regulation of key genes.It aims to provide a systematic reference for an in-depth understanding of the etiology of hypospadias.关键词
尿道下裂/环境内分泌干扰物/雄激素/邻苯二甲酸酯/发病机制Key words
hypospadias/endocrine disrupting chemicals/androgens/phthalates/pathogenesis分类
医药卫生引用本文复制引用
吴限,牛帅宇,汤井源,魏云飞..常见环境内分泌干扰物对尿道下裂的影响[J].岭南现代临床外科,2026,26(1):62-67,6.基金项目
江苏省中医药科技发展计划项目(MS2021018) （MS2021018）
新疆维吾尔自治区卫生健康科技计划项目(2025001MXJCSYJST-GXM65408625) （2025001MXJCSYJST-GXM65408625）
伊犁哈萨克自治区科技计划项目(YJC2023A30 （）
YJC2025B43) （）
江苏省中医院科主任学术提升专项课题(Y2022ZR27) （Y2022ZR27）
