皮肤性病诊疗学杂志2026，Vol.33Issue(2)：102-110,9.DOI:10.3969/j.issn.1674-8468.2026.02.004
樱花组合物的应用研究:敏感头皮护理与防脱发功效
A study on the application of Prunus Speciosa Composition:Efficacy for sensitive scalp care and anti-hair loss
黄鹏 1张柏慧 2梁锦茵 2叶理 2何健 1何平 1卢舒绮 1顾少杰 1罗剑芳 1李东翠 1姜乃生 3傅小晏2
作者信息
- 1. 花安堂生物科技集团有限公司,广东 广州 511400
- 2. 南方医科大学皮肤病医院,广东 广州 510091||南方医科大学,国家药品监督管理局监管科学创新研究基地,广东 广州 510515
- 3. 北京科技大学材料科学与工程学院,北京 100083||后摩尔时代芯片关键新材料与器件教育部重点实验室,北京 100083
- 折叠
摘要
Abstract
Objective To verify the effects of a cost-effective,low-concentration,and sensi-tive scalp-friendly anti-hair loss cherry blossom composition(PSC),aimed at overcoming the limi-tations of existing strategies which focus solely on stopping hair loss while neglecting the scalp care,and the reliance on a single cherry blossom extract at high concentration.Methods The composition of PSC was prepared,and the DPPH antioxidant assay was used to evaluate its free radical scavenging ability.The inhibition of PSC on TNF-α and IL-1 β was assessed to evaluate its soothing effect.The effects of PSC on oil control and prevention of hair loss were measured by as-sessing the inhibition of 5α-reductase activity in both the liver and epididymis.A total of 30 sub-jects with sensitive scalps were enrolled in this study.A 12-week clinical trial was conducted to e-valuate hair loss and overall hair density,and a questionnaire was used to assess the scalp condi-tion,hair density,and prevention of hair loss.Results The DPPH radical scavenging rate of PSC was 8.03％.PSC inhibited TNF-α and IL-1β by 30.70％and 44.40％,respectively,while in-hibiting 5 α-reductase by 42.59％(epididymis-derived)and 37.50％(liver-derived).Treatment of the scalp with a scalp essence for 12 weeks decreased hair loss by 14.79％(P＜0.001),while increasing hair density by as much as 33.33％,with an average increase of 5.32％(P＜0.05).Questionnaires showed that over 80％ of participants reported decreased scalp sebum secretion,re-duced sensitivity or discomfort,and noticeable reduction in hair loss.Conclusion PSC with a low concentration of PS can achieve the dual efficacy in scalp care and anti-hair loss,providing a high-ly effective and cost-efficient solution for individuals with sensitive scalps.关键词
樱花组合物/敏感头皮/防脱发/体外测试/临床评估Key words
Prunus Speciosa Composition/sensitive scalp care/anti-hair loss/in vitro assays/clinical evaluation引用本文复制引用
黄鹏,张柏慧,梁锦茵,叶理,何健,何平,卢舒绮,顾少杰,罗剑芳,李东翠,姜乃生,傅小晏..樱花组合物的应用研究:敏感头皮护理与防脱发功效[J].皮肤性病诊疗学杂志,2026,33(2):102-110,9.
