皮肤性病诊疗学杂志2026，Vol.33Issue(2)：111-116,6.DOI:10.3969/j.issn.1674-8468.2026.02.005
A型肉毒毒素联合曲安奈德注射及脉冲染料激光可显著改善病理性瘢痕
Clinical observation of botox-A combined with triamcinolone acetonide injection and pulsed dye laser in the treatment of pathological scars
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of combined treatment with botulinum toxin type A(BTX-A)injections,triamcinolone acetonide(TAC)injections,and pulsed dye laser(PDL)therapy for pathological scars.Methods A retrospective analysis was conducted on patients with hypertrophic scars or keloids diagnosed at Guangzhou Dermatology Hos-pital from January 2022 to September 2023.The treatment protocol for one cycle(3 months)com-prised a single perilesional injection of BTX-A in the first month,followed by intralesional injec-tion of TAC solution combined with PDL therapy in both the second and third months.Patients re-ceived 2 to 4 such cycles.Evaluations were performed before treatment,at 6 months(mid-treat-ment),and at the 6-month follow-up after treatment completion.Assessment tools included the vancouver scar scale(VSS)and a physician's global assessment,and adverse events were recor-ded.Results Twelve patients(4 males,8 females),aged 23-65 years(mean:38.4 years),with 15 scars were included.The VSS scores were 10.60±2.64 at pre-treatment,6.33±2.90 at mid-treatment,and 4.53±2.39 at the 6-month follow-up.The differences in VSS scores across these time points were statistically significant(F=101.71,P＜0.001).The VSS score at mid-treatment was significantly lower than the pre-treatment score,with a further significant reduction at the 6-month follow-up compared to the pre-treatment(both P＜0.001).Clinical assessment in-dicated significant improvement in 10 scars and improvement in 5 scars,resulting in a significant improvement rate of 66.67％ and an overall effective rate of 100％.Mild adverse events were ob-served in four cases,including telangiectasia(2 cases),folliculitis(1 case),and local epidermal necrosis(1 case).Conclusion The combination therapy of BTX-A,TAC injections,and PDL significantly improves pathological scars with minimal adverse effects.关键词
A型肉毒毒素/曲安奈德/局部注射/病理性瘢痕Key words
botulinum toxin type A/triamcinolone acetonide/local injection/pathologi-cal scars引用本文复制引用
熊小雨,陈教全,李萍,陈凤仪,龚业青,林日华,林玲..A型肉毒毒素联合曲安奈德注射及脉冲染料激光可显著改善病理性瘢痕[J].皮肤性病诊疗学杂志,2026,33(2):111-116,6.基金项目
2025年度市校(院)企联合资助专题项目(2025A03J3934) （院）
