皮肤性病诊疗学杂志2026，Vol.33Issue(2)：142-147,6.DOI:10.3969/j.issn.1674-8468.2026.02.010
沙眼衣原体逃避宿主固有免疫的研究进展
Advances in the innate immune evasion by Chlamydia trachomatis
摘要
Abstract
Chlamydia trachomatis(Ct)is the pathogen responsible for the most common bac-terial sexually transmitted disease.Its unique intracellular survival mode and complex immune evasion mechanisms enable it to establish long-term infections within the host,triggering severe chronic pathological reactions.This review provides insights into Ct's biological characteristics and various innate immune evasion strategies.The key roles of the cGAS-STING signaling pathway and crucial innate immune cells in host anti-infection responses are emphasized.The molecular mecha-nisms by which Ct achieves immune evasion,such as interfering with the γ-interferon response,manipulating host cell death,and inhibiting antigen presentation,are also elaborated.关键词
沙眼衣原体/免疫逃逸/宿主固有免疫/cGAS-STING信号通路/γ-干扰素Key words
Chlamydia trachomatis/immune evasion/host innate immunity/cGAS-STING signaling pathway/γ-interferon引用本文复制引用
陈语真,薛耀华,陈文韬..沙眼衣原体逃避宿主固有免疫的研究进展[J].皮肤性病诊疗学杂志,2026,33(2):142-147,6.基金项目
广东省自然科学基金(2023A1515012021,2024A1515220022) （2023A1515012021,2024A1515220022）
