陕西中医2026，Vol.47Issue(3)：360-365,6.DOI:10.3969/j.issn.1000-7369.2026.03.013
基于"诸痿发于肺热"理论探讨TGF-β1/Smad信号通路在间质性肺病并发骨质疏松症中的作用机制
Exploring the role of TGF-β1/Smad signaling pathway in interstitial lung disease with osteoporosis based on the theory of"all impotence originates from lung heat"
摘要
Abstract
Interstitial lung disease(ILD)is a group of diseases with diffuse alveolitis and interstitial fibrosis as the main pathological manifestations.Osteoporosis(OP)is one of the common complications of ILD,which is mani-fested by decreased bone mass and bone strength.In Chinese medicine,ILD and OP belong to the categories of"lung impotence"and"bone impotence",respectively,and the interaction and coexistence of ILD and OP pose a great chal-lenge to clinical diagnosis and treatment,which seriously affects the quality of patient's survival.The TGF-β1/Smad signaling pathway shows positive and negative feedback regulation in interstitial fibrosis and bone metabolism.Ab-normal TGF-β1/Smad signaling is closely related to lung fever,which disturbs the homeostasis of the internal envi-ronment and plays an important role in the development of ILD combined with OP.Based on the theory of"all impo-tence originates from lung heat"in Chinese medicine,this article discusses the mechanism of TGF-β1/Smad signaling pathway in ILD with osteoporosis,with the aim of providing a new theoretical basis for clinical diagnosis and treat-ment and ideas for targeted therapy.关键词
间质性肺病/骨质疏松症/诸痿发于肺热/肺热叶焦/TGF-β1/Smad信号通路/作用机制Key words
Interstitial lung disease/Osteoporosis/All impotence originates from lung heat/The scorched lung/TGF-β1/Smad signaling pathway/Mechanism of action分类
医药卫生引用本文复制引用
郑秀莲,林建平,雷良枭,汪冬梅,孙漪凡,陈少清..基于"诸痿发于肺热"理论探讨TGF-β1/Smad信号通路在间质性肺病并发骨质疏松症中的作用机制[J].陕西中医,2026,47(3):360-365,6.基金项目
国家自然科学基金资助面上项目(81973924) （81973924）
福建省财政资助专项(X2021003) （X2021003）
