上海预防医学2026，Vol.38Issue(1)：26-34,9.DOI:10.19428/j.cnki.sjpm.2026.250348
孕期PM2.5暴露诱导子代神经发育受损的meta分析
A meta-analysis of prenatal PM2.5 exposure and offspring neurodevelopmental impairment
摘要
Abstract
[Objective]By reviewing existing literature and conducting a meta-analysis,this study aimed to investigate the critical window(s)of exposure to PM2.5 during pregnancy on offspring neurodevelopmental impairments and provide a reference basis for individual-level protection against PM2.5 exposure during pregnancy.[Methods]All literature on the associations between prenatal PM2.5 exposure and offspring neurodevelopmental impairments were searched from the three English databases including PubMed,Elsevier's ScienceDirect,and Web of Science.Studies reporting odds ratio(OR)values for exposure during the first,second,and third trimesters,according to predetermined criteria,were selected for meta-analysis.[Results]A total of 14 studies were included in the final analysis.The meta-analysis of the extracted ORs revealed significant associations between PM2.5 exposure during all three trimesters and offspring neurodevelopmental impairments.The critical window showing the strongest association was observed during the second trimester(OR=1.11,95%CI:1.04‒1.18),followed by the first trimester(OR=1.10,95%CI:1.04‒1.15)and the third trimester(OR=1.09,95%CI:1.02‒1.16).[Conclusion]PM2.5 exposure during all gestational periods was positively correlated with an increased risk of neurodevelopmental impairments in offspring,with the strongest association observed during the second trimester.This period warrants targeted protective measurements for prenatal PM2.5 exposure.关键词
PM2.5/孕期暴露/敏感暴露窗口/子代/神经发育受损/meta分析Key words
PM2.5/prenatal exposure/sensitive exposure window/offspring/neurodevelopment impairment/meta analysis分类
医药卫生引用本文复制引用
田亮,尹洁云,苏越,严慰慈,王建书,信丽丽..孕期PM2.5暴露诱导子代神经发育受损的meta分析[J].上海预防医学,2026,38(1):26-34,9.基金项目
苏州市应用基础研究(医疗卫生)青年项目(SYW2024178) （医疗卫生）
苏州市"科教强卫"面上项目(MSXM2024037) （MSXM2024037）
