现代检验医学杂志2026，Vol.41Issue(2)：167-173,7.DOI:10.3969/j.issn.1671-7414.2026.02.028
基于TCGA数据库对多种肿瘤HMGA1基因表达与诊断及预后相关性分析
Analysis of HMGA1 Gene Expression and Its Correlation with Diagnosis and Prognosis in Multiple Cancers Based on TCGA Database
摘要
Abstract
Objective To explore the potential significance of high mobility group A1(HMGA1)protein in multiple cancers.Methods Utilizing data from The Cancer Genome Atlas(TCGA),GEPIA2,cBioPortal,and Gene Set Cancer Analysis(GSCA)databases,HMGA1 expression differences between cancerous and adjacent non-cancerous tissues were evaluated by the Wilcox-on signed-rank test.Univariate COX proportional hazards analysis and Kaplan-Meier methods were applied for survival analysis.Spearman correlation tests explored associations between HMGA1 expression and immune infiltrating cells,tumor mutational burden(TMB),and microsatellite instability(MSI).Results HMGA1 was significantly upregulated and correlated with prog-nosis across multiple cancers.Correlation analyses unveiled relationships between HMGA1 and the immune microenvironment,TMB,and MSI.Gene Set Enrichment Analysis(GSEA)revealed HMGA1's involvement in cytokine and chemokine signaling,cell cycle regulation,and antigen processing and presentation.HMGA1 expression correlated with sensitivity to drugs,including TGX221 and CCT007093.Conclusions HMGA1 holds potential as a pan-cancer biomarker for diagnosis and prognosis.关键词
高迁移率族蛋白A1/肿瘤微环境/药物敏感性/癌症基因组图谱/泛癌Key words
high mobility group A1/tumor microenvironment/drug sensitivity/The Cancer Genome Atlas/pan-cancer分类
医药卫生引用本文复制引用
赵东霞,秦伟珅,王慜杰..基于TCGA数据库对多种肿瘤HMGA1基因表达与诊断及预后相关性分析[J].现代检验医学杂志,2026,41(2):167-173,7.基金项目
科技部重大专项(2023ZD0509500). （2023ZD0509500）
