现代检验医学杂志2026，Vol.41Issue(2)：181-186,6.DOI:10.3969/j.issn.1671-7414.2026.02.030
超重/肥胖相关射血分数保留型心力衰竭患者血清TyG指数对中重度心室舒张功能障碍的预测价值分析
Predictive Value of Serum TyG Index for Moderate-to-Severe Ventricular Diastolic Dysfunction in Patients with Overweight/Obesity-Related Heart Failure with Preserved Ejection Fraction
摘要
Abstract
Objective To evaluate the predictive value of serum triglyceride-glucose(TyG)index for moderate-to-severe left ven-tricular diastolic dysfunction(LVDD)in overweight/obese patients with heart failure with preserved ejection fraction(HFpEF).Methods Clinical data of 227 patients with overweight/obesity-related HFpEF hospitalized at the Affiliated Hospital of Xuzhou Medical University from January 2023 to January 2024 were retrospectively collected.Patients were stratified into four quartiles based on TyG index values:low(n=57),low-moderate(n=58),moderate-high(n=56),and high(n=56).Differences in echocar-diographic parameters were compared across the four groups.Spearman's correlation was used to evaluate the association be-tween TyG index and moderate-to-severe LVDD.Logistic regression model was performed to identify independent risk factors for moderate-to-severe LVDD,and to generate receiver operating characteristic(ROC)curves.Binary Logistic regression analy-sis was performed in subgroups stratified by sex,age,diabetes status,and body mass index(BMI)to identify high-risk popula-tions.Results Compared with the other three groups,the high TyG group exhibited statistically significant increase in left atrial diameter(LAD),mitral early-to-atrial peak velocity ratio(E/A),and mitral early diastolic velocity to septal early diastolic myo-cardial velocity ratio(E/e')(F=4.306～9.954,all P＜0.05).Spearman correlation analysis indicated a positive association between TyG index and the risk of moderate-to-severe LVDD in overweight or obese HFpEF patients(r=0.452,P＜0.05).The results of multivariate Logistic regression analysis showed that high TyG index,HbA1c,LDL-C,and BMI were independent risk factors(Wald x2=4.011～17.478,all P＜0.05).ROC curve analysis demonstrated good predictive performance of the TyG index,with an AUC of 0.762(95％CI:0.701～0.823).Combining TyG index with HbA1c further improved AUC to 0.801(95％CI:0.745～0.857),yielding a sensitivity of 91.3％and a specificity of 57.7％.Subgroup analysis showed that eleveated TyG index was significantly associated with moderate-to-severe LVDD acroll all subgroups stratified by sex,age,diabetes status and BMI(OR=2.423～7.798,all P＜0.05).Conclusions The TyG index is a risk factor for moderate-to-severe LVDD in overweight or obese HF-pEF patients.Its combination with HbA1c enhances predictive accuracy.Moreover,TyG index demonstrated a consistent risk-predictive value across rarious populations.关键词
甘油三酯-葡萄糖指数/射血分数保留型心力衰竭/超重/肥胖/左心室舒张功能障碍Key words
triglyceride-glucose index/heart failure with preserved ejection fraction/overweight/obese/ventricular diastolic dysfunction分类
医药卫生引用本文复制引用
盛楚凡,王琲,王错错,赵旭东,李雷..超重/肥胖相关射血分数保留型心力衰竭患者血清TyG指数对中重度心室舒张功能障碍的预测价值分析[J].现代检验医学杂志,2026,41(2):181-186,6.基金项目
江苏省研究生科研与实践创新计划项目(SJCX24_1539). （SJCX24_1539）
