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DeepCodon:A deep learning codon-optimization model to enhance protein expression

Xudong Han Xiaoping Liao Jian Cheng Huifeng Jiang Xiaotong Shao Shuo Liu Zhenkun Shi Rong Huang Huanyu Chu Hejian Zhang Ruoyu Wang Haoran Li

生物设计研究（英文）2025，Vol.7Issue(4)：1-8,8.

生物设计研究（英文）2025，Vol.7Issue(4)：1-8,8.DOI:10.1016/j.bidere.2025.100042

DeepCodon:A deep learning codon-optimization model to enhance protein expression

Xudong Han ¹Xiaoping Liao ²Jian Cheng ³Huifeng Jiang ³Xiaotong Shao ¹Shuo Liu ¹Zhenkun Shi ²Rong Huang ¹Huanyu Chu ³Hejian Zhang ¹Ruoyu Wang ²Haoran Li²

作者信息

1. College of Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,PR China||Key Laboratory of Engineering Biology for Low-carbon Manufacturing,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,PR China
2. Key Laboratory of Engineering Biology for Low-carbon Manufacturing,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,PR China||Biodesign Center,Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences,Tianjin 300308,PR China
3. Key Laboratory of Engineering Biology for Low-carbon Manufacturing,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,PR China||National Center of Technology Innovation for Synthetic Biology,Tianjin 300308,PR China
折叠

摘要

关键词

Deep learning/Protein expression/Bioinformatics/Codon optimization

Key words

Deep learning/Protein expression/Bioinformatics/Codon optimization

引用本文复制引用

Xudong Han,Xiaoping Liao,Jian Cheng,Huifeng Jiang,Xiaotong Shao,Shuo Liu,Zhenkun Shi,Rong Huang,Huanyu Chu,Hejian Zhang,Ruoyu Wang,Haoran Li..DeepCodon:A deep learning codon-optimization model to enhance protein expression[J].生物设计研究（英文）,2025,7(4):1-8,8.

基金项目

This project has received funding from the Strategic Priority Research Program of the Chinese Academy of Sciences XDC0120200,National Natural Science Foundation of China(32371499,12326611),COMSATS Joint Center for Industrial Biotechnology(No.TSBICIP-IJCP-001),Tianjin Synthetic Biotechnology Innovation Capacity Improve-ment Project(No.TSBICIP-IJCP-002,TSBICIP-CYFH-011,TSBICIP-KJGG-009-02,TSBICIP-KJGG-008-02,TSBICIP-KJGG-018,TSBICIP-PTJJ-012),and major research projects of the Haihe Laboratory of Synthetic Biology(No.22HHSWSS00005 and 22HHSWSS00004). （32371499,12326611）

生物设计研究（英文）

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