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Four enzymes from button bush enable de novo biosynthesis of spirooxindole alkaloids in yeast

Alyssa Dawn Seveck Jacob Owen Perley Di Gao Jiazhang Lian Yang Qu

生物设计研究（英文）2025，Vol.7Issue(4)：31-38,8.

生物设计研究（英文）2025，Vol.7Issue(4)：31-38,8.DOI:10.1016/j.bidere.2025.100049

Four enzymes from button bush enable de novo biosynthesis of spirooxindole alkaloids in yeast

Alyssa Dawn Seveck ¹Jacob Owen Perley ¹Di Gao ²Jiazhang Lian ³Yang Qu¹

作者信息

1. Department of Chemistry,University of New Brunswick,Fredericton,E3B 5A3,Canada
2. Key Laboratory of Biomass Chemical Engineering of Ministry of Education,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou,China
3. Key Laboratory of Biomass Chemical Engineering of Ministry of Education,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou,China||ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University,Hangzhou,China||Zhejiang Key Laboratory of Smart Biomaterials,Zhejiang University,Hangzhou,China
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摘要

关键词

Monoterpenoid indole alkaloids/Spirooxindole/MIA C3-epimerization/de novo oxindole biosynthesis/Cytochrome P450 monooxygenase

Key words

Monoterpenoid indole alkaloids/Spirooxindole/MIA C3-epimerization/de novo oxindole biosynthesis/Cytochrome P450 monooxygenase

引用本文复制引用

Alyssa Dawn Seveck,Jacob Owen Perley,Di Gao,Jiazhang Lian,Yang Qu..Four enzymes from button bush enable de novo biosynthesis of spirooxindole alkaloids in yeast[J].生物设计研究（英文）,2025,7(4):31-38,8.

基金项目

This research is supported by a Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant and a New Brunswick Innovation Foundation(NBIF)Research Assistantship Initiative Grant to Y.Q. （NSERC）

生物设计研究（英文）

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