畜牧与兽医2026，Vol.58Issue(4)：135-141,7.
抗菌肽的优化及在兽医领域的研究进展
Optimization of antimicrobial peptides and its research progress in veterinary applications
摘要
Abstract
Antimicrobial peptides(AMPs)are natural host defense molecules widely distributed in animals,plants,and microorganisms.They exhibit broad-spectrum antibacterial,antiviral,antifungal,and immunomodulatory activities,showing great potential for diverse appli-cations.However,natural AMPs are often limited by poor structural stability,susceptibility to enzymatic degradation,high cytotoxicity,and elevated production costs,which hinder their further development and practical use.This review systematically summarizes recent advances in the structural optimization of AMPs,including amino acid sequence modification,peptide cyclization,polymer conjugation,computer-aided drug design(CADD),bioengineering expression systems,and nanocarrier-based delivery strategies.Moreover,progress in the veterinary application of AMPs is highlighted,particularly in their roles as feed additives,therapeutic agents for clinical diseases,vaccine adjuvants,and treatments in companion animal medicine.This work is intended to provide valuable reference and theoretical support for future research on and application of AMPs in veterinary medicine.关键词
抗菌肽/结构优化/临床应用/疾病防治/饲料添加剂Key words
antimicrobial peptides/structural optimization/clinical application/disease prevention and control/additives分类
农业科技引用本文复制引用
谢欢,于岩飞,祁子泰,陈琢琦,李志强,袁晓民,张炜,邵国青,李敏,冯志新..抗菌肽的优化及在兽医领域的研究进展[J].畜牧与兽医,2026,58(4):135-141,7.基金项目
宁夏回族自治区重点研发计划项目(2025BBF02009) （2025BBF02009）
国家自然科学基金项目(32172860) （32172860）
江苏省科协青年科技人才托举工程项目(JSTJ-2023-XH031) （JSTJ-2023-XH031）
