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Berberine alleviates radiation-induced lung injury by promoting microbiota-derived inosine via the gut-lung axis

Shuyuan Wang Siyuan Huai Zhen Yuan Tiannan Ji Yinmei Xu Yifan Ren Niansong Qian Shengjie Sun Jianxiong Li

微生物与宿主健康（英文）2026，Vol.4Issue(3)：165-185,21.

微生物与宿主健康（英文）2026，Vol.4Issue(3)：165-185,21.DOI:10.1016/j.hlife.2025.12.006

Berberine alleviates radiation-induced lung injury by promoting microbiota-derived inosine via the gut-lung axis

Shuyuan Wang ¹Siyuan Huai ²Zhen Yuan ³Tiannan Ji ⁴Yinmei Xu ²Yifan Ren ⁵Niansong Qian ⁶Shengjie Sun ⁷Jianxiong Li²

作者信息

1. Department of Radiotherapy,Senior Department of Oncology,The Fifth Medical Center of PLA General Hospital,Beijing,China||Division of Medicine,University College London,London,UK||School of Medicine,Nankai University,Tianjin,China
2. Department of Radiotherapy,Senior Department of Oncology,The Fifth Medical Center of PLA General Hospital,Beijing,China
3. School of Medicine,Nankai University,Tianjin,China||Centre for Human Genetics,University of Oxford,Oxfordshire,UK
4. Department of Emergency,The Fifth Medical Center of PLA General Hospital,Beijing,China
5. Department of Radiotherapy,Senior Department of Oncology,The Fifth Medical Center of PLA General Hospital,Beijing,China||School of Medicine,Nankai University,Tianjin,China
6. Department of Thoracic Oncology,Senior Department of Respiratory and Critical Care Medicine,The Eighth Medical Center of PLA General Hospital,Beijing,China
7. Senior Department of Oncology,The Fifth Medical Center of PLA General Hospital,Beijing,China
折叠

摘要

关键词

radiation-induced lung injury/gut-lung axis/berberine/gut microbiota/epigenetic modification

Key words

radiation-induced lung injury/gut-lung axis/berberine/gut microbiota/epigenetic modification

引用本文复制引用

Shuyuan Wang,Siyuan Huai,Zhen Yuan,Tiannan Ji,Yinmei Xu,Yifan Ren,Niansong Qian,Shengjie Sun,Jianxiong Li..Berberine alleviates radiation-induced lung injury by promoting microbiota-derived inosine via the gut-lung axis[J].微生物与宿主健康（英文）,2026,4(3):165-185,21.

基金项目

This work was supported by the National Natural Science Foun-dation of China(grant number 82373515 to J.L.). （grant number 82373515 to J.L.）

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