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Pan-prediction of major histocompatibility complex class Ⅱ-restricted epitopes across species via an AlphaFold-based quantification scheme

Suqiu Wang Lifeng Zhang Sheng Wang Shi Xu Hanchun Yang Nianzhi Zhang Lingming Kong Dongmei Hu Liangzhen Zheng Caiyi Fei Liubao Du Ziche Tang Malgorzata A.Garstka Onur Serçinoğlu

微生物与宿主健康（英文）2026，Vol.4Issue(3)：186-204,19.

微生物与宿主健康（英文）2026，Vol.4Issue(3)：186-204,19.DOI:10.1016/j.hlife.2025.10.005

Pan-prediction of major histocompatibility complex class Ⅱ-restricted epitopes across species via an AlphaFold-based quantification scheme

Suqiu Wang ¹Lifeng Zhang ²Sheng Wang ³Shi Xu ⁴Hanchun Yang ⁵Nianzhi Zhang ⁵Lingming Kong ⁴Dongmei Hu ⁵Liangzhen Zheng ⁶Caiyi Fei ⁴Liubao Du ⁵Ziche Tang ⁵Malgorzata A.Garstka ⁷Onur Serçinoğlu⁸

作者信息

1. State Key Laboratory of Veterinary Public Health and Safety,Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,China Agricultural University,Beijing,China||Animal Quarantine Institute,Science and Technology Research Center of China Customs,Beijing,China
2. Department of Resources,Science and Technology Research Center of China Customs,Beijing,China
3. Shanghai Zelixir Biotech Company Ltd.,Shanghai,China||CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Guangdong,China
4. Nanjing Chengshi Biomedical Technology(TheraRNA)Co.,Ltd.,Jiangsu,China
5. State Key Laboratory of Veterinary Public Health and Safety,Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,China Agricultural University,Beijing,China
6. Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Guangdong,China||Shanghai Zelixir Biotech Company Ltd.,Shanghai,China
7. Department of Endocrinology,The Second Affiliated Hospital of Xi'an Jiaotong University,Shaanxi,China||Core Research Laboratory,The Second Affiliated Hospital of Xi'an Jiaotong University,Shaanxi,China
8. Department of Bioengineering,Faculty of Engineering,Gebze Technical University,Kocaeli,Türkiye
折叠

摘要

关键词

major histocompatibility complex class Ⅱ(MHC-Ⅱ)-restricted epitope/AlphaFold-prediction(AF-pred)/vaccine design/pan-predicting

Key words

major histocompatibility complex class Ⅱ(MHC-Ⅱ)-restricted epitope/AlphaFold-prediction(AF-pred)/vaccine design/pan-predicting

引用本文复制引用

Suqiu Wang,Lifeng Zhang,Sheng Wang,Shi Xu,Hanchun Yang,Nianzhi Zhang,Lingming Kong,Dongmei Hu,Liangzhen Zheng,Caiyi Fei,Liubao Du,Ziche Tang,Malgorzata A.Garstka,Onur Serçinoğlu..Pan-prediction of major histocompatibility complex class Ⅱ-restricted epitopes across species via an AlphaFold-based quantification scheme[J].微生物与宿主健康（英文）,2026,4(3):186-204,19.

基金项目

This study was supported by the National Key Research and Development Program of China(grant number 2021YFD1800100 to N.Z.),the National Natural Science Foun-dation of China(grant number 32172871 to N.Z.),the 2115 Talent Development Program of China Agricultural University to N.Z.This study was supported by High-performance Computing Platform of China Agricultural University. （grant number 2021YFD1800100 to N.Z.）

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