医学信息2026，Vol.39Issue(5)：22-27,6.DOI:10.3969/j.issn.1006-1959.2026.05.004
基于孟德尔随机化分析的肠道菌群和新生儿高胆红素血症因果关联研究
Study on the Causal Relationship Between Intestinal Flora and Neonatal Hyperbilirubinemia Based on Mendelian Randomization Analysis
孔德进 1高阳1
作者信息
- 1. 临沂市中心医院儿科,山东 临沂 276400
- 折叠
摘要
Abstract
Objective To explore the causal relationship between intestinal flora and neonatal hyperbilirubinemia by Mendelian randomization method.Methods Using the summary data of large sample genome-wide association study(GWAS),the genetic loci closely related to neonatal hyperbilirubinemia were selected as instrumental variables.Two-sample Mendelian randomization analysis was performed using inverse variance weighting method,MR-Egger regression,weighted median,simple model and weighted model to evaluate the causal relationship between intestinal flora and neonatal hyperbilirubinemia.Results The inverse variance weighting method showed that Bifidobacterium(OR=0.2733,95%CI:0.0918-0.8133)and Kreuzella adelbrueckii(OR=0.2733,95%CI:2.0085-26.7286)were causally associated with neonatal hyperbilirubinemia.The results of MR-Egger regression,weighted median,simple model and weighted model were consistent with those of inverse variance weighting method.Conclusion There is a negative causal relationship between the abundance of Bifidobacterium and the risk of neonatal hyperbilirubinemia.关键词
肠道菌群/新生儿高胆红素血症/孟德尔随机化Key words
Intestinal flora/Neonatal hyperbilirubinemia/Mendelian randomization分类
医药卫生引用本文复制引用
孔德进,高阳..基于孟德尔随机化分析的肠道菌群和新生儿高胆红素血症因果关联研究[J].医学信息,2026,39(5):22-27,6.
