畜牧与兽医2026，Vol.58Issue(4)：21-28,8.
低聚糖对蛋鸡生产性能、抗氧化和免疫功能的影响
Effects of oligosaccharides on the production performance,antioxidant,and immunefunction of laying hens
摘要
Abstract
This study aimed to evaluate the effects of different oligosaccharides on the production performance,antioxidant capacity,and immune function of laying hens.A total of 448 healthy 500-day-old laying hens were obtained and randomly assigned to 4 groups,with 8 replicates per group and 14 hens per replicate.The hens were fed with either a basal diet(CON)or experimental diets supplemented with 20 mg/kg chitosan oligosaccharides(COS),50 mg/kg xylooligosaccharides(XOS),or 500 mg/kg mannan oligosaccharides(MOS).The ex-perimental period lasted for 56 days.The results showed that,compared with the CON group,the COS,XOS,and MOS groups significantly reduced the average daily feed intake of the laying hens(P＜0.05).These oligosaccharides significantly increased the serum albumin content and total antioxidant capacity levels(T-AOC)in the birds,but reduced the serum low-density lipoprotein cholesterol content in them(P＜0.05).Specifically,COS enhanced serum total superoxide dismutase(T-SOD)and hepatic catalase(CAT)activities(P＜0.05),whereas MOS improved ovarian T-SOD activity and uterine T-AOC levels(P＜0.05)of the hens.COS and MOS up-regulated the mRNA expression of nuclear factor erythroid 2-related factor 2(Nrf2)in both the liver and ovaries(P＜0.05)of the hens.All three oligosaccharides up-regu-lated hepatic superoxide dismutase 1(SOD1)mRNA expression(P＜0.05),and MOS also elevated its expression in their ovaries.The mRNA expression of hepatic glutathione peroxidase 1(GPX1)in the hens was significantly enhanced by all supplements(P＜0.05).For cat-alase(CAT),COS and XOS up-regulated its hepatic mRNA expression,while COS up-regulated and XOS down-regulated its ovarian ex-pression(P＜0.05).Both COS and MOS significantly increased the mRNA expression of heme oxygenase-1(HO-1)in the liver and ovaries(P＜0.05).XOS and MOS increased serum immunoglobulin A(IgA)content,and COS increased immunoglobulin G(IgG)content(P＜0.05).All the three oligosaccharides significantly reduced the serum content of interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)(P＜0.05).In conclusion,dietary supplementation with COS,XOS,and MOS improved antioxidant status,regulated gene ex-pression in the liver and ovary,and enhanced immune parameters and overall health of the laying hens.关键词
低聚糖/蛋鸡/生产性能/抗氧化能力/免疫Key words
oligosaccharides/laying hens/productive performance/antioxidant capacity/immunity分类
农业科技引用本文复制引用
王胜家,高铁,杨一丁,李继博,邵云,张瑜,周岩民..低聚糖对蛋鸡生产性能、抗氧化和免疫功能的影响[J].畜牧与兽医,2026,58(4):21-28,8.基金项目
江苏现代农业(蛋鸡)产业技术体系项目(JATS[2023]425) （蛋鸡）
