中国临床药学杂志2026，Vol.35Issue(1)：23-28,6.DOI:10.19577/j.1007-4406.2026.01.004
妊娠期缺铁性贫血患者使用口服铁剂的临床综合评价指标体系构建
Construction of clinical comprehensive evaluation index system for oral iron supplementation in patients with iron deficiency anemia during pregnancy
摘要
Abstract
AIM A comprehensive clinical evaluation framework for oral iron supplementation in patients with iron deficiency anemia during pregnancy has been established to guide rational clinical practice.METHODS The Guidelines for the Management of Comprehensive Clinical Evaluation of Drugs(Trial Edition 2021)was used as an important basis,and relevant literature was referenced to fully consider the characteristics of anemia in special groups during pregnancy when developing a questionnaire for expert consultation.Two rounds of expert consultation were conducted using the Delphi method to determine the final index system for the clinical comprehensive evaluation of the rational use of oral iron supplementation for patients with iron supplementation deficiency anemia during pregnancy.RESULTS After 2 rounds of expert consultation and expert consensus meeting,a clinical comprehensive evaluation index system for the use of oral iron supplementation in patients with iron deficiency anemia during pregnancy was finally determined,including 6 first-level indicators,13 second-level indicators and 31 third-level indicators.The weights of safety,effectiveness,economy,suitability,accessibility and innovation of the first-level indicators were 0.176 6,0.184 1,0.166 7,0.159 2,0.164 2 and 0.149 3,respectively.The expert positive coefficients of the 2 rounds of expert consultation were 100％,and the expert authority coefficients were 0.93 and 0.96,respectively.The difference in Kendall's coordination coefficient was statistically significant(P＜0.01).CONCLUSION The clinical comprehensive evaluation index system for the use of oral iron supplementation in patients with iron deficiency anemia during pregnancy is highly authoritative,scientific,representative and feasible,which helps to improve the rationality and standardization of the use of oral iron supplementation in patients with iron supplementation deficiency anemia during pregnancy.关键词
药品临床综合评价/妊娠期/口服铁剂/德尔菲法Key words
clinical comprehensive evaluation of drugs/pregnancy/oral iron supplementation/Delphi method分类
医药卫生引用本文复制引用
陈伟,焦萍,李国辉..妊娠期缺铁性贫血患者使用口服铁剂的临床综合评价指标体系构建[J].中国临床药学杂志,2026,35(1):23-28,6.基金项目
山东省第二批药品临床综合评价项目(编号2022YZ016) （编号2022YZ016）
山东省医学会临床科研资金-齐鲁专项(编号YXH2022ZX02073) （编号YXH2022ZX02073）
