中国塑料2026，Vol.40Issue(3)：42-47,6.DOI:10.19491/j.issn.1001-9278.2026.03.008
递送西他列汀的分段式聚合物微针的成型工艺及扩散性能表征
Fabrication technology and transdermal diffusion performance of segmented polymer microneedles for sitagliptin delivery
摘要
Abstract
This study presents the design,fabrication,and characterization of segmented polymer microneedles for the transder-mal delivery of sitagliptin.The microneedle geometry and array architecture were specifically engineered to enable efficient drug administration.Comprehensive evaluations of morphology,dimensional accuracy,and mechanical properties confirmed that the fabricated microneedles possess sufficient structural integrity to reliably penetrate the stratum corneum.In vitro transdermal dif-fusion tests demonstrated rapid and sustained drug release:72.3%of the loaded sitagliptin was released within 2 min,and cu-mulative release reached 97.1%by 10 min.These results highlight the excellent drug release kinetics and potential clinical utili-ty of the developed system.Given sitagliptin's therapeutic relevance in metabolic disorders,this microneedle platform offers a promising,minimally invasive strategy for the management of obesity and related conditions.关键词
药物释放/分段式结构/肥胖症/微针阵列/西他列汀Key words
drug release/segmented structure/obesity/microneedle array/sitagliptin分类
化学化工引用本文复制引用
康晓雅,庄俭,霍则军,张浩琳,孟秀丽,胡晓青,朱敬先,原福贞,高强,彭荣梅..递送西他列汀的分段式聚合物微针的成型工艺及扩散性能表征[J].中国塑料,2026,40(3):42-47,6.基金项目
北京大学第三医院创新转化基金/海淀转化专项"计划(HDCXZHKC2023208) （HDCXZHKC2023208）
北京大学第三医院创新与转型基金(BYSYZH-KC2023112) （BYSYZH-KC2023112）
北医三院创新转化基金项目(BYSYZHZB202521) （BYSYZHZB202521）
