中国实验动物学报2026，Vol.34Issue(2)：246-256,11.DOI:10.3969/j.issn.1005-4847.2026.02.010
溃疡性结肠炎及大肠湿热病证结合动物模型的研究现状及思考
Syndrome current research landscape and critical reflections on disease-syndrome integrated animal models of ulcerative colitis with large-intestine damp-heat syndrome
摘要
Abstract
Ulcerative colitis(UC)is a chronic inflammatory bowel disease with a multifactorial etiology that poses considerable challenges to effective treatment.Traditional Chinese medicine(TCM)has demonstrated favorable therapeutic outcomes in the management of UC,and the development of disease-syndrome integrated animal models has emerged as a critical approach for bridging TCM and modern biomedical research.We systematically reviewed the main strategies for constructing UC animal models,with a specific focus on modeling protocols tailored to the TCM syndrome of large intestine damp-heat.These approaches encompass multifactorial induction pathways involving dietary,environmental,and microbial stimuli.In terms of model evaluation,emphasis was placed on integrating modern omics technologies,such as metabolomics and metagenomics,to enhance the objectivity and quantifiability of TCM syndrome identification in experimental models.We also summarize recent advances in the integration of gene-edited models with damp-heat induction method,providing a conceptual framework for composite models that better simulate the complex interplay between UC pathogenesis and individual constitutional characteristics.These integrative models,supported by refined construction techniques and multidimensional evaluation systems,have the potential to improve scientific rigor and translational relevance,offering a robust experimental foundation for elucidating the mechanisms of TCM-based interventions in UC.关键词
溃疡性结肠炎/病证结合/动物模型/组学评价Key words
ulcerative colitis/disease-syndrome combination/animal model/omics-based evaluation分类
生物科学引用本文复制引用
周浩,马祥雪,方泽彬,吴皓萌,黄绍刚..溃疡性结肠炎及大肠湿热病证结合动物模型的研究现状及思考[J].中国实验动物学报,2026,34(2):246-256,11.基金项目
国家自然科学基金(82341231,82174318),广东省自然科学基金面上项目(2021A1515011498),省部共建中医湿证国家重点实验室专项(SZ2021ZZ0203,SZ2021ZZ44,SZ2021ZZ13,SZ2021ZZ25),东莞市高水平医院建设专项项目(20231800916372).Funded by National Natural Science Foundation of China(82341231,82174318),Natural Science Foundation of Guangdong Province General Program(2021A1515011498),Special Project of the State Key Laboratory of Damp Syndrome in Traditional Chinese Medicine Jointly Built by the Ministry and the Province(SZ2021ZZ0203,SZ2021ZZ44,SZ2021ZZ13,SZ2021ZZ25),Dongguan High-Level Hospital Construction Special Project(20231800916372). （82341231,82174318）
