中国比较医学杂志2026，Vol.36Issue(4)：76-84,9.DOI:10.3969/j.issn.1671-7856.2026.04.007
兔脑浸液与脂多糖诱导家兔弥散性血管内凝血模型在医学实验教学中的比较研究
Comparison of rabbit brain infusion and lipopolysaccharide-induced diffuse intravascular coagulation models for medical laboratory teaching
摘要
Abstract
To compare the application value of rabbit brain infusion(TF)and lipopolysaccharide(LPS)-induced disseminated intravascular coagulation(DIC)models in medical laboratory teaching,this study systematically contrasts these two classical models across four dimensions:pathogenic mechanisms,modeling techniques,detection systems,and teaching application design.Results indicate that the TF model simulates acute traumatic DIC through exogenous coagulation activation,while the LPS model mimics chronic infectious DIC via endogenous inflammatory-coagulation cascades.Both models exhibit complementary characteristics in pathogenesis timing,indicator profiles,and experimental skill training.Teaching optimization strategies grounded in mechanism-oriented approaches,skill-tiered training,and clinical mapping can effectively enhance students' understanding of DIC's complex pathological processes and practical competencies.This provides theoretical justification and a feasible teaching design framework for selecting and integrating DIC models in medical experimental education.关键词
DIC模型/兔脑浸液/脂多糖/医学实验教学/医学机能学Key words
DIC model/rabbit brain infusion/lipopolysaccharide/medical laboratory teaching/medical functionalism分类
社会科学引用本文复制引用
饶玉良,张亚东,严钰锋..兔脑浸液与脂多糖诱导家兔弥散性血管内凝血模型在医学实验教学中的比较研究[J].中国比较医学杂志,2026,36(4):76-84,9.基金项目
教育部产学合作协同育人项目(220901282154531) （220901282154531）
教育部基础学科拔尖学生培养计划2.0研究课题(20212025). （20212025）
