中国比较医学杂志2026，Vol.36Issue(4)：100-107,8.DOI:10.3969/j.issn.1671-7856.2026.04.010
Nrf2/HO-1信号通路调控脑缺血再灌注损伤的研究进展
Research progress on regulation of cerebral ischemia-reperfusion injury by Nrf2/HO-1 signaling pathway
摘要
Abstract
Cerebral ischemia-reperfusion injury(CIRI)is a key pathological link in the deterioration of neurological function after stroke.Its mechanism is closely related to oxidative stress and the inflammatory response,and ultimately leads to severe neuronal damage.The nuclear factor E2-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling pathway,which mediates endogenous protective effects,has recently received extensive attention.This pathway plays a central role in maintaining cellular redox homeostasis by regulating antioxidant,anti-inflammatory,and anti-apoptotic processes.This review explores the activation mechanism and multi-directional protective effect of the Nrf2/HO-1 signaling pathway in CIRI,and analyzes the therapeutic potential of targeting this pathway,to provide a theoretical basis for the development of new neuroprotective drugs to optimize clinical treatment strategies and improve the prognosis of patients with CIRI.关键词
Nrf2/HO-1信号通路/脑缺血再灌注损伤/保护Key words
Nrf2/HO-1 signaling pathway/cerebral ischemia-reperfusion injury/protection分类
医药卫生引用本文复制引用
梁涵,邓洋,娄超,于进南,董志强,石瑞丽..Nrf2/HO-1信号通路调控脑缺血再灌注损伤的研究进展[J].中国比较医学杂志,2026,36(4):100-107,8.基金项目
国家自然科学基金(82360788) （82360788）
包头医学院公共卫生与预防医学一流培育学科科研项目(GWGG-20250806). （GWGG-20250806）
