摘要
Abstract
Objective To investigate the effect of 308 nm excimer light combined with halometasone encapsulation in the treatment of vitiligo.Methods A total of 82 vitiligo patients admitted to Henan Hongli Hospital from January 2022 to March 2025 were selected and divided into a control group and an observation group according to different treatment methods.The control group(41 cases)received 308 nm excimer light treatment,while the observation group(41 cases)received additional treatment with halometasone on top of the control group.The treatment effects of the two groups were compared.Results The total effective rate of the observation group was 95.12%(39/41),which was higher than the control group's 80.49%(33/41),and the difference was statistically significant(P<0.05);Before treatment,there was no statistically significant difference in the skin lesion area score and skin color score between the two groups of patients(P>0.05).After treatment,the above scores decreased in both groups of patients,and the observation group had a lower score,with a statistically significant difference(P<0.05);Before treatment,there was no statistically significant difference in the levels of inflammatory factors between the groups(P>0.05).After treatment,the observation group had lower levels of inflammatory factors,and the difference was statistically significant(P<0.05);Before treatment,there was no statistically significant difference in T cell subpopulation indicators between groups(P>0.05).After treatment,the observation group had higher levels of CD3+and CD4+,and lower levels of CD8+,with statistically significant differences(P<0.05);The satisfaction level of the observation group patients was significantly higher,and the difference was statistically significant(P<0.05).Conclusions The combination of halometasone encapsulation and 308 nm excimer light therapy is effective in treating vitiligo,promoting skin lesion repair,improving skin color abnormalities,inhibiting inflammatory mediator levels,regulating immune function,and achieving high patient satisfaction.关键词
308 nm准分子光/卤米松封包治疗/白癜风/炎症因子/免疫功能Key words
308 nm excimer light/halometasone package therapy/vitiligo/inflammatory factors/immune function
