中国中医药科技2026，Vol.33Issue(1)：5-9,5.
针药结合干预帕金森前驱期疾病易感状态的机制研究
Research on the Mechanism of Acupuncture Combined with Traditional Chinese Medicine in Intervening the Susceptibility State of Parkinson's Disease in Prodromal Stage
摘要
Abstract
Objective:To explore the mechanism of acupuncture combined with traditional Chinese medicine intervention in the susceptible state of Parkinson's disease in the prodromal stage.Methods:DA content in the striatum of rats,TLR2 levels in the substantia nigra,hippocampus,olfactory bulb,and colon of rats were detected by ELISA;behavioral indicators related to emotional stress in rats were evaluated,including sucrose solution preference rate and tail suspension immobility time;behavioral indicators related to sleep in rats were evaluated,including sleep latency and sleep duration.Results:As the susceptible state of Parkinson's disease in the prodromal stage gradually progressed,DA content gradually decreased,and TLR2 levels in the substantia nigra,hippocampus,olfactory bulb,and colon gradually increased;after acupuncture-medicine combination treatment,the sucrose solution preference rate was significantly increased,the tail suspension immobility time was reduced,the sleep latency was shortened,and the sleep duration was prolonged.Conclusion:Acupuncture combined with traditional Chinese medicine can reverse the predisposition to Parkinson's disease in the prodromal stage.关键词
帕金森/帕金森前驱期/疾病易感状态/情志应激/针药结合Key words
Parkinson's disease/Parkinson's prodromal stage/disease susceptibility state/emotional stress/acupuncture combined with Traditional Chinese Medicine引用本文复制引用
徐珂,李元,胡丙成,张宇,白妍,王顺..针药结合干预帕金森前驱期疾病易感状态的机制研究[J].中国中医药科技,2026,33(1):5-9,5.基金项目
国家自然科学基金面上项目(82474664) （82474664）
