中医杂志2026，Vol.67Issue(4)：386-391,6.DOI:10.13288/j.11-2166/r.2026.04.008
代谢相关脂肪性肝病的中医诊疗研究现状及展望
Research Advances of Traditional Chinese Medicine Diagnosis and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease:Overview and Prospects
摘要
Abstract
The pathogenesis of metabolic dysfunction-associated steatotic liver disease(MASLD)is fundamentally rooted in spleen deficiency and is closely associated with phlegm turbidity,damp-heat and blood stasis.Clinically,liver constraint with spleen deficiency and internal retention of damp turbidity represent the predominant traditional Chinese medicine(TCM)syndrome patterns.Researches have indicated intrinsic connections between the syndrome patterns and biological indicators such as gut microbiota and metabolic profiles.Regarding treatment,classical famous formulas,modern empirical formulas,and newly developed TCM drugs show positive effects in regulating glucose and lipid metabolism,improving insulin resistance,and alleviating metabolic inflammation,exhibiting multi-target mech-anisms of action;acupuncture and other external therapies also provide adjunctive value.Nevertheless,current re-searches still have limitations such as the lack of high-quality clinical evidence and insufficient systematic elucidation of the uncerlying mechanisms.Future efforts should focus on conducting high-quality TCM clinical trials with hard endpoint outcomes such as hepatic histology outcomes,and utilizing modern technologies like multi-omics to elucidate TCM's mechanisms of action,thereby advancing the position of TCM as a first-line therapeutic strategy for MASLD.关键词
代谢相关脂肪性肝病/中医药疗法/文献综述Key words
metabolic dysfunction-associated steatotic liver disease/traditional Chinese medicine therapy/literature review引用本文复制引用
戴亮,季光,王宪波,张莉,徐汉辰,唐旭东..代谢相关脂肪性肝病的中医诊疗研究现状及展望[J].中医杂志,2026,67(4):386-391,6.基金项目
中国科学技术协会2024年中医脾胃病学学科发展研究(2024XKFZYJ) （2024XKFZYJ）
