中医杂志2026，Vol.67Issue(4)：410-415,6.DOI:10.13288/j.11-2166/r.2026.04.012
胃癌前病变中医药防治研究现状及展望
Current Status and Prospects of Research on Traditional Chinese Medicine Prevention and Treatment for Gastric Precancerous Lesions
摘要
Abstract
Traditional Chinese medicine(TCM),through its multi-target and systematic regulatory effects,has demonstrated unique advantages in the treatment of gastric precancerous lesions(GPL).At present,TCM theoretical research on GPL is mainly reflected in three aspects,the integration of macroscopic syndrome differentiation,the inflammation-carcinoma transformation mechanism,as well as the systematization and scientization of theoretical inheritance from famous TCM practitioners.High-quality evidence-based research findings serve as the foundation for clinical practice guidelines on GPL,and TCM has gained international academic recognition in the field of GPL pre-vention and treatment.Research on TCM mechanisms has yielded a series of important outcomes in the aspects of sig-naling pathways,gene expression regulation,cellular epigenetics,histone modification,and intestinal microecology.It is proposed that future research on GPL should focus on four key directions,establishing multi-omics data,explor-ing targeted intervention strategies on key regulatory nodes,advancing the standardization process of integrated tradi-tional Chinese and western medicine prevention and treatment technologies,and constructing stratified screening and intervention platforms.The in-depth integration of TCM microcosmic mechanism of action with its macroscopic syn-drome differentiation and treatment system,coupled with interdisciplinary research,will provide valuable references for the clinical treatment and scientific research of GPL.关键词
胃癌前病变/中医药疗法/炎-癌转化/文献综述Key words
gastric precancerous lesions/traditional Chinese medicine therapy/inflammation-carcinoma transfor-mation/literature review引用本文复制引用
白海燕,张泰,王萍,刘林,徐伟超,田亚欣,胡蓝烁,杨倩,唐旭东..胃癌前病变中医药防治研究现状及展望[J].中医杂志,2026,67(4):410-415,6.基金项目
国家中医药管理局国家中医药传承与创新团队项目(ZYYCXTD-C-202010) （ZYYCXTD-C-202010）
中国科学技术协会2024年中医脾胃病学学科发展研究(2024XKFZYJ) （2024XKFZYJ）
中国中医科学院西苑医院提升高水平临床研究和成果转化能力试点建设项目(XYZX0204-03) （XYZX0204-03）
中国中医科学院科技创新工程(CI2021A01004) （CI2021A01004）
中国中医科学院科技创新工程创新团队项目(CI2021B005) （CI2021B005）
