安徽大学学报（自然科学版）2026，Vol.50Issue(2)：80-88,9.DOI:10.3969/j.issn.1000-2162.2026.02.010
基于全基因组数据的中华菊头蝠种群分化格局与遗传脆弱性评估
Genome-wide insights into population differentiation and genetic vulnerability in the Chinese horseshoe bat(Rhinolophus sinicus)
摘要
Abstract
To elucidate the patterns of population differentiation and population viability in the Chinese horseshoe bat(Rhinolophnus sinicus),we performed whole-genome sequencing on 40 individuals sampled from eight provinces across China.Population genetic analyses based on high-density single-nucleotide polymorphisms identified,for the first time at the whole-genome scale,three highly differentiated genetic lineages:the Southeast region group,the Mid-Western region group,and the Yunnan region group.We further systematically characterized the genetic load of these three lineages and found that the Yunnan region group exhibited the highest accumulation of homozygous deleterious mutations,indicating that this lineage likely experienced severe historical population bottlenecks and prolonged genetic drift,and thus resulted in reduced genetic diversity and pronounced genetic vulnerability.At the whole-genome level,our study reveals a tight association between population differentiation and the accumulation of genetic load in R.sinicus,providing new insights into its evolutionary history and establishing a genomic basis for conservation prioritization,particularly for the Yunnan population,as well as for the risk management of bat-associated diseases.关键词
遗传分化/遗传负荷/中华菊头蝠/群体遗传学/全基因组测序Key words
gentic differentiation/genetic load/Rhinolophus sinicus/population genetics/whole-genome sequencing分类
生物科学引用本文复制引用
王雨婷,谢慧娴,张盛,欧阳林霞,刘超,王志林,潘涛,黄广平..基于全基因组数据的中华菊头蝠种群分化格局与遗传脆弱性评估[J].安徽大学学报（自然科学版）,2026,50(2):80-88,9.基金项目
国家自然科学基金资助项目(32192420) （32192420）
科技部基础资源调查专项(2021FY100300) （2021FY100300）
