北京中医药大学学报2026，Vol.49Issue(3)：384-391,8.DOI:10.3969/j.issn.1006-2157.2026.03.010
基于"虚气留滞"从免疫偏倚和训练免疫论治儿童腺样体肥大
Treating pediatric adenoidal hypertrophy from the perspectives of immune bias and trained immunity based on the"deficiency-qi stagnation"
摘要
Abstract
The pathogenesis of pediatric adenoidal hypertrophy is closely associated with deficiency-qi stagnation.Physiological predispositions,along with immune bias and trained immunity imbalance resulting from inadequate postnatal environmental modulation,contribute to the development of an immune-inflammatory microenvironment that promotes pathological lymphoid hyperplasia and,in advanced cases,tissue fibrosis.Therefore,a systematic pathogenic framework is proposed,comprising two interrelated mechanisms:deficiency-qi as the underlying predisposing factor for immune dysregulation,and phlegm accumulation and blood stasis as contributors to maladaptive immune priming.These two pathological processes,deficiency-qi and phlegm-blood stasis,are not isolated but dynamically interact and mutually reinforce one another.Therapeutic strategies should reinforce the essence of the kidney,enhance vital energy,promote recovery of physiological function,use warming herbs to harmonize the zang organs,and regulate the lung and stomach by descending Yangming qi,all of which address the root deficiency and help restore immune homeostasis.Additionally,identifying and eliminating latent pathogenic factors,such as retained heat and dampness,and resolving endogenous wind and the underlying disturbance of"impaired qi transformation"is essential.Such a comprehensive approach may modulate immune regulation and rebalance immune responses,thereby providing valuable insights into the disease mechanism and contributing to improved clinical outcomes.关键词
虚气留滞/痰饮/瘀血/腺样体肥大/免疫偏倚/训练免疫Key words
deficiency-qi stagnation/phlegm and fluid retention/blood stasis/adenoidal hypertrophy/immune bias/trained immunity分类
医药卫生引用本文复制引用
窦玉珠,戴启刚,翟思明,李涛,王媛媛,袁斌..基于"虚气留滞"从免疫偏倚和训练免疫论治儿童腺样体肥大[J].北京中医药大学学报,2026,49(3):384-391,8.基金项目
江苏省中医药科技发展计划项目(No.ZD202219) （No.ZD202219）
2025年度江苏省中医流派研究院重点课题(No.LPZD2025012) （No.LPZD2025012）
江苏省中医药科技发展计划项目重点项目(No.ZD202412) Jiangsu Province Traditional Chinese Medicine Science and Technology Development Plan Project(No.ZD202219) （No.ZD202412）
