北京中医药大学学报2026，Vol.49Issue(3)：401-406,6.DOI:10.3969/j.issn.1006-2157.2026.03.012
基于"膏脂生邪"探讨高脂血症的中医证治
Traditional Chinese medicine syndrome differentiation and treatment on hyperlipidemia based on"pathogenic factors arising from Gao and Zhi"
摘要
Abstract
Hyperlipidemia is a key risk factor for atherosclerotic cardiovascular and cerebrovascular diseases,and its traditional Chinese medicine(TCM)pathogenesis is closely associated with the abnormal metabolism of"Gao"(a thick,viscous fluid that moisturizes and nourishes the skin,muscles,and joints)and"Zhi"(a more solid substance that stores energy and provides warmth).Hyperlipidemia initiates with the impairment of"Kunyuan,"namely,spleen-stomach deficiency,leading to insufficient digestion and transportation.Subsequently,it progresses to"Shuyao"dysfunction,characterized by liver and gallbladder dysfunction in regulating qi movement,coupled with impaired ascending and descending functions of the middle energizer,leading to qi stagnation.This,in turn,causes the abnormal transformation of essential substances,leading to the failure of"Gao"and"Zhi"transportation and their transformation into turbid lipids that infiltrate the blood vessels.Ultimately,stagnation congeals internally:turbid lipids transform into phlegm and obstruct the vessels to form stasis,thereby resulting in phlegm-stasis interbinding,which corresponds to atherosclerotic plague in western medicine.In response to this dynamic pathogenesis,a systematic therapeutic principle is proposed:"strengthening earth(spleen)to nourish Kunyuan,activating Shuyao to facilitate Sanjiao(triple energizer),mobilizing Gao and Zhi to expel turbid lipids,and resolving stagnation to unblock collaterals."This approach intervenes at four levels:strengthening and consolidating body resistance,regulating qi movement,expulsing pathogen-dredging collateral,and resolving stagnation-dispersing bind.Based on"pathogenic factors arising from Gao and Zhi,"this article systematically expounds the core pathogenesis evolution process of hyperlipidemia,namely"Kunyuan-Shuyao-Gao and Zhi-obstruction and stagnation,"which fully embodies the TCM principles of treatment aiming at its root cause and preventing disease from exacerbating.关键词
膏脂生邪/脂质/高脂血症/辨证论治Key words
pathogenic factors arising from Gao and Zhi/lipids/hyperlipidemia/treatment based on syndrome differentiation分类
医药卫生引用本文复制引用
胡雅璐,陈铭泰,谢雨昕,黎倩倩,庾浩杨,黄立新,林洁雨,简文,栾杰男..基于"膏脂生邪"探讨高脂血症的中医证治[J].北京中医药大学学报,2026,49(3):401-406,6.基金项目
中医药广东省实验室(广东省科技计划项目)横琴粤澳深度合作区深合中药新药技术创新中心首期建设项目(No.HQCML-C-2024005) （广东省科技计划项目）
深圳市自然科学基金面上项目(No.JCYJ20240813152440051) （No.JCYJ20240813152440051）
深圳市医学研究专项资金(No.A2403028) Guangdong Provincial Laboratory of Traditional Chinese Medicine(Guangdong Provincial Science and Technology Program Project)-Phase I Construction Project of the Shenhe Innovation Center for New Traditional Chinese Medicine Drugs in the Hengqin Guangdong-Macao In-Depth Cooperation Zone(No.HQCML-C-2024005) （No.A2403028）
