成都中医药大学学报2026，Vol.49Issue(2)：6-11,6.DOI:10.13593/j.cnki.51-1501/r.2026.02.002
基于"龙战-玄黄"象思维探讨麻黄类方"以战促和"治疗肌萎缩侧索硬化症三维临床范式构建
Constructing A Three-Dimensional Clinical Paradigm for ALS Treatment Based on the"Dragon Struggle-Yellow Earth"Im-age Thinking Using Ephedra-Based Formulas with A"Conflict-Promoting Harmony"Strategy
摘要
Abstract
The current study,inspired by the philosophical concept of"Dragon Struggle in the Wild,Blood Turning Black and Yellow"from the Zhouyi(I Ching),innovatively constructs a"Dragon Struggle-Yuanhuang"three-dimensional pathogenesis model.This model reveals the pathological evolution of ALS characterized by"dysregulation of opening/closing and ascending/descending movements-im-paired Qi transformation-disharmony of Yin-Yang."Through integrative analysis of classical formulas and disease patterns,it was discov-ered that Ma Huang-based formulas target the mechanisms of"opening pores to promote ascending/descending movements-regulating Qi transformation-harmonizing Yin-Yang,"demonstrating precise correspondence with the hyperactive,transitional,and remission phases of the disease.Clinical verification using biomarkers such as"sweating as a sign of recovery"and"improved urination"confirms the efficacy of"harmony through struggle"achieved by these formulas through regulation of the neuro-endocrine-immune network.This research in-tegrates philosophical modeling,classical interpretation,and clinical validation,proposing a novel TCM diagnostic and therapeutic para-digm of"interconnected form and essence,harmonious mind and body"for ALS.关键词
龙战-玄黄/三维契合临床模式/麻黄类方/以战促和/肌萎缩侧索硬化症/临床转化/医案Key words
Longzhan-Xuanhuang/Three-Dimensional aligned clinical model/Ephedra-Based formulas/Promote harmony through battle/Amyotrophic lateral sclerosis/Clinical translation/Medical case分类
医药卫生引用本文复制引用
程善廷,黄素结,黄郁斌,石丽飞,文豪,张保国..基于"龙战-玄黄"象思维探讨麻黄类方"以战促和"治疗肌萎缩侧索硬化症三维临床范式构建[J].成都中医药大学学报,2026,49(2):6-11,6.基金项目
第六批全国中医临床优秀人才研修项目(中医药青年拔尖人才培养项目)(国中医药人教函[2025]256号) （中医药青年拔尖人才培养项目）
广东省"十四五"省级中医药临床特色专科建设项目(粤中医函[2025]11号) （粤中医函[2025]11号）
全国基层名老中医药专家(张保国)传承工作室(国中医药人教函[2024]256号) （张保国）
