结直肠肛门外科2026，Vol.32Issue(1)：83-89,7.DOI:10.19668/j.cnki.issn1674-0491.2026.01.012
基于脑肠轴理论指导的雷火灸对直肠癌低位前切除综合征的临床疗效观察
Observation on the clinical efficacy of thunder-fire moxibustion guided by the brain-gut axis theory for low anterior resection syndrome in rectal cancer
摘要
Abstract
Objectives To investigate the clinical effect of thunder-fire moxibustion guided by the brain-gut axis theory on low anterior resection syndrome(LARS)in rectal cancer.Methods A total of 66 patients who developed LARS after rectal cancer surgery and were admitted to the Department of General Surgery,Jiangsu Province Hospital of Traditional Chinese Medicine from October 2023 to October 2024 were selected as study subjects.They were divided into a control group(routine care intervention group)and an observation group(thunder-fire moxibustion group)using a random num-ber table method,with 33 patients in each group.After excluding dropouts,61 patients were finally included in the study,with 31 in the control group and 30 in the observation group.The two groups were compared in terms of defeca-tion function(assessed using the LARS Scale),anal function(anal resting pressure,maximum anal squeeze pressure,and maximum tolerable rectal volume),serum biomarkers(cortisol,serotonin[5-HT],interleukin-6[IL-6]),and quality of life(assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30[EORTC QLQ-C30]).Results After 4 weeks of treatment,the LARS scores in both groups were lower than before treat-ment,and the score in the observation group was significantly lower than that in the control group;the LARS severity grade in the observation group was significantly better than that in the control group(P＜0.05).The anal resting pres-sure,maximum anal squeeze pressure,and maximum tolerable rectal volume in both groups increased compared to be-fore treatment levels,these parameters were significantly higher in the observation group than in the control group(P＜0.05).Serum levels of cortisol,5-HT,and IL-6 in both groups decreased compared to before treatment levels,and these levels were significantly lower in the observation group than in the control group(P＜0.05).The observation group showed significantly better outcomes than the control group in five functional domains,fatigue,sleep disturbance,diar-rhea,and constipation(P＜0.05).Conclusion Thunder-fire moxibustion can improve clinical symptoms,enhance anal con-tinence function,reduce serum levels of cortisol,5-HT,and IL-6,and improve the quality of life in patients with LARS to a certain extent.关键词
直肠癌/低位前切除综合征/雷火灸/脑肠轴/生活质量Key words
rectal cancer/low anterior resection syndrome/thunder-fire moxibustion/brain-gut axis/quality of life分类
医药卫生引用本文复制引用
章颖,许睿,居月月,宫晓晓,王晓红,王欢欢,江志伟,王晓庆..基于脑肠轴理论指导的雷火灸对直肠癌低位前切除综合征的临床疗效观察[J].结直肠肛门外科,2026,32(1):83-89,7.基金项目
江苏省中医药管理局2024年度省中医药科技发展计划项目(MS2024023) （MS2024023）
江苏省中医院2023年度南丁格尔专项课题(Y23005) （Y23005）
江苏省重点学科项目(ZDXK202251) （ZDXK202251）
