大连理工大学学报2026，Vol.66Issue(2)：119-126,8.DOI:10.7511/dllgxb202602002
紫外老化聚乳酸微塑料对大鳞副泥鳅的毒性研究
Toxicity study of UV-aged polylactic acid microplastics to Paramisgurnus dabryanus
摘要
Abstract
Polylactic acid microplastics(PLA-MPs)are widely present in the environment and can age under ultraviolet radiation,posing a potential threat to aquatic organisms.Characterization analysis is conducted on aged PLA-MPs,and the enrichment of aged PLA-MPs at different concentrations in the liver of juvenile Paramisgurnus dabryanus is explored,as well as their effects on liver tissue damage,hepatocyte apoptosis,mitochondrial function,and lipid accumulation.The characterization results indicate that compared with the original microplastics(MPs),the aged MPs have a rough surface with cracks,reduced particle size,increased oxygen to carbon ratio and enhanced hydrophilicity.In addition,toxicity test results show that the accumulation of aged PLA-MPs in various tissues of juvenile fish is proportional to their concentration,and can cause severe liver tissue damage,intensified hepatocyte apoptosis,decreased mitochondrial membrane potential,and abnormal lipid accumulation.关键词
老化PLA-MPs/组织损伤/肝细胞凋亡/脂质积累Key words
aged PLA-MPs/tissue damage/hepatocyte apoptosis/lipid accumulation分类
医药卫生引用本文复制引用
宋红玉,孟倩,易先亮,许沅江,周豪,刘阳..紫外老化聚乳酸微塑料对大鳞副泥鳅的毒性研究[J].大连理工大学学报,2026,66(2):119-126,8.基金项目
国家自然科学基金资助项目(41606131). （41606131）
