大连理工大学学报2026，Vol.66Issue(2)：127-132,6.DOI:10.7511/dllgxb202602003
基于网络药理学探讨五味子乙素抑制胰腺癌AKT通路
Inhibition of AKT pathway of pancreatic cancer by schisandrin B based on network pharmacology
摘要
Abstract
Schisandrin B(SchB)is the most abundant dibenzocyclooctadiene lignan in Chinese magnolia vine fruit,but research on its role in pancreatic cancer,which has an extremely poor prognosis,remains limited.To further investigate the mechanism by which SchB inhibits pancreatic cancer,experiments are conducted using pancreatic cancer PANC-1 cells as a model.MTT assays show that SchB inhibits cell proliferation in a concentration-dependent manner;when combined with gemcitabine(GEM),it exhibits significant chemosensitization effects;Transwell invasion assays confirm that the drug effectively suppresses cell invasion.Based on these findings,network pharmacology is further employed to predict the molecular mechanisms and biological functions of SchB in pancreatic cancer.Western Blot analysis demonstrates that SchB inhibits the AKT pathway;comet assay results confirm that it promotes DNA damage,thereby verifying the predictions of network pharmacology.In summary,the findings indicate that SchB has the potential to become a therapeutic agent for pancreatic cancer or a sensitizer for gemcitabine.关键词
胰腺癌/网络药理学/五味子乙素/AKT通路/吉西他滨/DNA损伤Key words
pancreatic cancer/network pharmacology/schisandrin B(SchB)/AKT pathway/gemcitabine(GEM)/DNA damage分类
医药卫生引用本文复制引用
王璇琪,郑仁,张馨敏,徐佳,肖桂山..基于网络药理学探讨五味子乙素抑制胰腺癌AKT通路[J].大连理工大学学报,2026,66(2):127-132,6.基金项目
国家自然科学基金资助项目(81770846). （81770846）
