陆军军医大学学报2026，Vol.48Issue(6)：663-669,7.DOI:10.16016/j.2097-0927.202601070
神经系统调控肿瘤:从环路机制到靶向干预的交叉前沿
Neurological regulation of tumors:An interdisciplinary frontier from circuit mechanisms to targeted intervention
摘要
Abstract
Traditional oncology research has long focused on genetic,immunological,and vascular mechanisms.In recent years,with the deepening interdisciplinary convergence,"cancer neuroscience"has rapidly emerged as a cutting-edge field for deciphering the mechanisms of tumor initiation and progression.In this article,we systematically review the research trajectory of neural-tumor interactions:from the early observations of neural infiltration within tumors to recent breakthroughs revealing that the nervous system actively regulates tumor processes through multiple mechanisms.In intracranial tumors,glioma cells can form functional synapses with neurons,"hijacking"neural signals such as glutamate to drive their own proliferation.In peripheral solid tumors,specific brain circuits(e.g.,the amygdala-sympathetic nerve pathway)can remotely regulate the progression of cancers such as breast cancer;meanwhile,sympathetic,parasympathetic,and sensory nerves directly act on tumor cells or reshape the immune microenvironment through releasing neurotransmitters and neuropeptides,such as norepinephrine,acetylcholine,and calcitonin gene-related peptide(CGRP),thereby influencing tumor evolution.These findings collectively constitute a"neuro-immune-tumor"regulatory axis,providing a novel perspective for understanding tumor biology.Building upon our group's previous work,we propose that the nervous system represents an indispensable and active component of the tumor microenvironment,extensively participating in tumor initiation,progression,metastasis,and immune regulation through multi-level mechanisms involving electrical signals,chemical neurotransmitters,and neural circuits.Targeting neural-tumor interactions(e.g.,using β-blockers or modulating specific neural circuits)has already demonstrated significant translational potential for synergizing with existing therapies.Through integrating key advances in this field,we systematically elaborate the translational pathway from basic discoveries to clinical exploration,analyze current technical and clinical challenges,and prospect a forward-looking perspective on interdisciplinary collaboration and precision intervention,thereby,providing theoretical reference and framework for deepening the understanding of systemic tumor regulation and developing novel neuro-targeted therapeutic strategies.关键词
癌症神经科学/神经系统/肿瘤/肿瘤微环境/神经-免疫Key words
cancer neuroscience/nervous system/tumor/tumor microenvironment/neuroimmunity分类
医药卫生引用本文复制引用
张毅,熊斯怡..神经系统调控肿瘤:从环路机制到靶向干预的交叉前沿[J].陆军军医大学学报,2026,48(6):663-669,7.基金项目
国家自然科学基金(82403678),重庆市自然科学基金重点项目(CSTB2023NSCQ-ZDX0002),重庆市重大医学研究计划(重庆市卫生健康委与科技局联合项目,2024DBXM001) Supported by the National Natural Science Foundation of China(82403678),the Key Project of Natural Science Foundation of Chongqing(CSTB2023NSCQ-ZDX0002)and the Project of Major Medical Research Plan of Chongqing(Joint Project of Chongqing Health Commission and Chongqing Science and Technology Commission,2024DBXM001). （82403678）
