福建农林大学学报（自然科学版）2026，Vol.55Issue(2)：291-300,10.DOI:10.13323/j.cnki.j.fafu(nat.sci.).202503017
菌草灵芝醇提物对免疫损伤小鼠脾脏和肠道菌群的调节作用
Regulatory effect of alcohol extract of JUNCAO Ganoderma lucidum on spleenic and intestinal flora of immunosuppressive mice
摘要
Abstract
[Objective]The effect of JUNCAO Ganoderma lucidum alcohol extract(JGE)on the spleenic and intestinal flora of immu-nosuppressive mice was studied to provide reference for in-depth research and application of JUNCAO G.lucidum.[Method]The immu-nosuppressive BALB/c mice model were construced by cyclophosphamide,and then intervented with JGE by gavage.After the JGE in-tervention,the biochemical indicators and histopathological phenotypes of mice tissues were measured and observed,and the intestinal flora were investigated by 16S rRNA high-throughput sequencing.[Result]At a gavage dose of 200 mg·kg-1·d-1,JGE was contribu-ted to higher proliferation rate of splenic lymphocytes,greater number of splenocytes in the spleen,improvement of damaged spleen and cecum,regulated intestinal flora structure with increased diversity in immunosuppressive mice.Specifically,the abundances of ben-eficial bacteria such as Ruminococcus,Roseburia,Bacteroides,Odoribacter,and Coprococcus were increased,and the abundance of harm-ful bacteria such as Desulfovibrio,Staphylococcaceae,and Sporosarcina were decreased.[Conclusion]JGE was beneficial to the spleen and cecum of immunosuppressive mice,and can maintain the stability of intestinal internal environment by regulating intestinal flora.关键词
菌草灵芝/环磷酰胺/小鼠/脾脏/肠道菌群/免疫力Key words
JUNCAO Ganoderma lucidum/cyclophosphamide/mice/spleen/intestinal flora/immunity分类
轻工纺织引用本文复制引用
张凤丽,马乳平,黄文琪,陈濠,赵立娜..菌草灵芝醇提物对免疫损伤小鼠脾脏和肠道菌群的调节作用[J].福建农林大学学报（自然科学版）,2026,55(2):291-300,10.基金项目
国家重点研发计划(2023YFD1600503) （2023YFD1600503）
福建省科技重大专项(2021NZ029009). （2021NZ029009）
