广东医学2026，Vol.47Issue(2)：166-171,6.DOI:10.13820/j.cnki.gdyx.20251232
HBV合并甲状腺乳头状癌的临床病理学特征
Clinicopathological characteristics of papillary thyroid carcinoma concurrent with hepatitis B virus infection
摘要
Abstract
Objective To investigate the clinicopathological characteristics of patients with papillary thyroid car-cinoma(PTC)concurrent with hepatitis B virus(HBV)infection.Methods Clinical data and pathological reports of 14 patients diagnosed with HBV-positive PTC from January 2019 to June 2025 were retrospectively collected.Histopatholog-ical morphology was analyzed,and immunohistochemical markers were evaluated to characterize tumor phenotypes.Results The male-to-female ratio was 1.5∶1,with ages ranging from 30-60 years(median 45 years).Disease re-mained stable after surgical resection and levothyroxine therapy.Tumor tissues showed strong expression of CK19 and Ga-lectin-3,positivity for BRAF V600E,and absent or reduced expression of TPO and CD56.HBcAg,HBsAg,and AFP were not expressed in tumor samples.Compared with typical PTC patients,HBV-positive PTC patients demonstrated a higher likelihood of metastatic calcification involving the tumor capsule.Conclusion HBV-associated PTC occurs more frequently in men and predominantly affects middle-aged to older adults,with earlier onset in males.Lesions are mainly unilateral and often present as micro-PTC.The immunophenotype is characterized by expression of CK19,Galectin-3,and BRAF V600E,with loss or reduction of CD56 and TPO and absence of HBV antigens and AFP.HBV-positive PTC exhibits a higher probability of metastatic calcification extending to the capsule than conventional PTC.关键词
乙型肝炎病毒/甲状腺乳头状癌/临床病理Key words
hepatitis B virus/papillary thyroid carcinoma/clinical pathology分类
医药卫生引用本文复制引用
万晓晴,肖艳华,粟海霞,苏锦清,李栋兰,李莎莎,张付美,韩亚娟..HBV合并甲状腺乳头状癌的临床病理学特征[J].广东医学,2026,47(2):166-171,6.基金项目
广州市科技计划市校(院)企联合资助项目(2024A03J0861) （院）
