医学分子生物学杂志2026，Vol.23Issue(2)：156-163,8.DOI:10.3870/j.issn.1672-8009.2026.02.007
桔梗多糖对溃疡性结肠炎大鼠氧化应激和TLR/NF-κB、JAK2/STAT3信号通路的影响
Effect of Platycodon grandiflorum Polysaccharides on Oxidative Stress,TLR/NF-κB and JAK2/STAT3 Signaling Pathways in Rats with Ulcerative Colitis
摘要
Abstract
Objective To explore the effect of Platycodon grandiflorum polysaccharides on oxi-dative stress,and expression of Toll-like receptor(TLR)/nuclear transcription factor kappa B(NF-κB)and Janus kinase 2(JAK2)/signal transduction and activator of transcription 3(STAT3)signaling pathways-related factors in rats with ulcerative colitis(UC).Methods The UC rat model was constructed by dextran sulfate sodium(DSS),then UC rats were treated with different doses of Platycodon grandiflorum polysaccharides for 2 weeks.The disease activity index,pathological changes of colon,apoptosis,levels of inflammatory and oxidative stress factors,and expression levels of TLR4/NF-κB and JAK2/STAT3 related mRNA and proteins were ob-served.Results After treatment with Platycodon grandiflorum polysaccharides,the disease activity index,apoptosis rate of colon tissues,levels of IL-6,TNF-α,IL-17 and MDA were decreased,levels of IL-10,SOD and GSH-px were increased,expression levels of TLR4,NF-κB,JAK2,STAT3,and p-JAK2 and p-STAT3 in colon tissues were decreased,with a dose dependent manner(P<0.05).Conclusion Platycodon grandiflorum polysaccharides can alleviate colon injury and oxidative stress in colon tissues in UC rats,and inhibit the activation of TLR/NF-κB and JAK2/STAT3 pathways.关键词
溃疡性结肠炎/桔梗多糖/氧化应激/TLR/NF-κB信号通路/JAK2/STAT3信号通路Key words
ulcerative colitis/platycodon grandiflorum polysaccharides/oxidative stress/TLR/NF-κB signaling pathway/JAK2/STAT3 signaling pathway分类
医药卫生引用本文复制引用
李森,常健,刘清娥,袁芸菲,闫玲新..桔梗多糖对溃疡性结肠炎大鼠氧化应激和TLR/NF-κB、JAK2/STAT3信号通路的影响[J].医学分子生物学杂志,2026,23(2):156-163,8.基金项目
河北省中医药管理局科研项目(No.2024194) This work was supported by a grant from the Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(No.2024194) （No.2024194）
